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Diss Factsheets
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EC number: 249-616-3 | CAS number: 29420-49-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Information on bioaccumulation of PFBS-K salt is provided by laboratory studies in the aquatic (fish), sediment (worm), and terrestrial (worm, plant species) compartments. In addition, studies are available of mammals and birds (see Toxicological information). Due to its high water solubility and low adsorption coefficient, the most likely route of exposure is by water. Bioconcentration factors measured for fish, as well as feeding studies on fish and a BSAF calculated for the sediment worm Lumbriculus variegatus, indicate little potential for PFBS-K salt to accumulate in aquatic organisms. Similarly, tests conducted on earthworms of Genus Eisenia showed little potential for PFBS-K salt to accumulate in terrestrial organisms. Studies of plants grown in intentionally-dosed soil or hydroponically in exposed medium showed little tendency for PFBS-K salt to accumulate in terrestrial plants.
A feeding study performed on dairy cows (elsewhere in this dossier) did not report a BMF, but showed that PFBS was eliminated rapidly during depuration in urine. In the chronic avian toxicity test, liver and serum samples were taken and analyzed to address potential bioaccumulation. Serum PFBS concentrations in males and females were approximately 6- to 13-fold less than those measured in diet, while liver PFBS concentrations were approximately 30-to 56-fold less than that in the diet. Additionally, a biomagnification study was done on pigs (elsewhere in this dossier). This study was deemed unreliable (Klimisch 3) for several reasons. While the BMF was slightly greater than one, no analysis of experimental error was provided. The authors did not measure depuration rate constants, but rather used several assumptions to model various rates and calculate a BMF. The steady state concentration and elimination half-life estimates used to calculate BMF were based on the rate constants which showed a broad confidence interval. It is felt that the reported BMF has enough potential for error associated with several aspects of its calculation that it can be considered to not be statistically significantly different from 1. Further, the actual values measured in each compartment were not available for review and there are no time-matched tissue and blood data. It is not possible to verify the BMF calculation given the information presented in the paper.
In addition to biomagnification studies, toxicokinetic data from higher mammals are available (elsewhere in this dossier). These include estimated serum elimination half-lives in rodents (~ 4 hours), non-human primates (~ 96 hours), and occupationally exposed workers (~ 26 days). Additional toxicokinetic studies of more limited reliability are also available. Taken together, these results indicate rapid elimination from terrestrial organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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