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Diss Factsheets
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EC number: 232-137-9 | CAS number: 7788-97-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Acute - single dose
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Extensive testing has been performed on chromium and fluoride salts; since dissociation will occur if ingested, assessment of the ions is considered a valid approach. No further animal testing is justified.
The acute toxic effects and potential for irritation depend very much on the counter ions and pH. Salts with an extreme pH will be strongly irritant and perhaps corrosive to skin, and as such, will cause damage to skin, gastro-intestinal tract and respiratory system. Chromium fluoride as supplied is acidic and may induce local effects if tested on animals; performing new animal tests is not considered appropriate.
Sodium fluoride is soluble in water and has been tested for acute oral toxicity
Data source
Reference
- Reference Type:
- publication
- Title:
- Pathology of acute oral toxicity of sodium fluoride in Wistar rats
- Author:
- Giri D.K., Ghosh R.C., Mondal M
- Year:
- 2 014
- Bibliographic source:
- Indian Journal of Veterinary Pathology Year : 2014, Volume : 38, Issue : 1
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Principles of method if other than guideline:
- Individual rats were given increasing concentrations until adverse effects were seen.
- GLP compliance:
- not specified
- Test type:
- up-and-down procedure
- Limit test:
- no
Test material
- Reference substance name:
- Sodium fluoride
- EC Number:
- 231-667-8
- EC Name:
- Sodium fluoride
- Cas Number:
- 7681-49-4
- Molecular formula:
- FNa
- IUPAC Name:
- sodium fluoride
Constituent 1
- Specific details on test material used for the study:
- Sodium fluoride
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 112, 168 and 253 mg NaF/kg body weight (after initial screening at lower levels)
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 250 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- approximate LD50
- Effect level:
- ca. 230 mg/kg bw
- Based on:
- other: CrF3
- Mortality:
- Mortality observed at 253 mg/kg. No higher doses were used.
- Clinical signs:
- other: Local irritation, hyperactivity, tachypnea, colourless discharge from nostrils, eyes and salivation
- Gross pathology:
- Necropsy findings included generalised congestion in liver, heart, kidneys, spleen and brain. Watery mucous and froth were seen in stomach.
Histopathological screening of the liver sections fopund severe degenerative and necrotic changes in hepatocytes along with haemorrhages
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- On the basis that the toxicity of Na F was due to fluoride ions and in view of systemic effects being seen (liver) ruling out local corrosivity as a cause of mortality, this is conisdered a valid interpretation of toxicity for CrF3.
It is known that chromium III is not acutely toxic.
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