Registration Dossier
Registration Dossier
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EC number: 946-410-1 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with Column 2 of Annex IX (point 9.3.2) of Regulation EC 1907/2006, the study does not need to be conducted in the substance has a low potential to cross biological membranes. As the molecular weight range of the UVCB substance is >300 - 650 (average 475), is unlikely to undergo passive absorption. In addition, due to the low water solubility (0.05 mg/L) and the high partition coefficient (log Pow 6.02 - > 10), the material is expected to be highly lipophilic and more likely to partition to fat, but too hydrophobic to diffuse across biological membranes into highly aqueous environments. On this basis, the test is omitted due to the expected poor absorption.The OECD Toolbox also predicts no binding to protein for this substance. Protein binding has been shown to contribute to the bioconcentration potential of substances in aquatic species (Fairbrother et al. 2007; Cowan-Ellsberry et al. 2008; Franke 1996; Legierse et al. 1998; Tremolada et al. 2009; Veltman et al. 2006). The test item attained 74 % biodegradation after 28 days and can therefore considered to be readily biodegradable. The physicochemical properties of the test substance, and extensive ecotoxicity studies provide strong support in determining the bioaccumulation potential (not bioaccumulative) for this substance, and therefore may substitute for the experimentation of in vivo effects.
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
