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EC number: 224-030-0 | CAS number: 4170-30-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: publication
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
- Type of study / information:
- RD50
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Alaire 1966
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Crotonaldehyde
- EC Number:
- 224-030-0
- EC Name:
- Crotonaldehyde
- Cas Number:
- 4170-30-3
- Molecular formula:
- C4H6O
- IUPAC Name:
- but-2-enal
- Details on test material:
- Purchased from Aldrich Chemical Company, Milwaukee, Wisconsin
Purity 85-99 with the balance being water
Constituent 1
Results and discussion
Any other information on results incl. tables
B6C3F1 mice exposed to crotonaldehyde showed a rapid decrease in respiratory rate at the onset of exposure which sustained throughout the exposure period with little or no recovery. RD50 10 min = 4.88 (4.0 -6.3) ppm. Swiss-Webster mice usually exhibted a continuously decreasing respiratory rate during the exposure period, especially at higher exposure concentrations. RD50 10 min = 3.53 (2.88 -4.62) ppm.
Applicant's summary and conclusion
- Conclusions:
- Swiss-Webster mice RD50 10 min = 3.53 (2.88 -4.62) ppm.
- Executive summary:
3 -4 mice (B6C3F1 mice and swiss-webster mice) per group were exposured in a 2.7 liter head only exposure chamber for 10 min to concentrations of crotonaldehyde. Sensory irriation was quantified by measuring respiratory rate depression during these exposures. Respiratory rates were determined by a body plethysmographic method (Alaire 1966). The animals were sealed in an airtight body plethysmographs attached to the head only exposure chamber and allowed to acclimate for 10 min. Respiratory rates were recoreded during a 5 min preexposure, 10 min exposure, and 5 min recovery. The average maximum decrease in respiratory rate for 1 min was computed from the response of each gruop of animals and plotted versus the log of the exposure concentration. Usually 5 concentrations of aldehyde were used to construct a concentration response curve for which the RD50 (value at which there is a 50% decrease in respiratory rate) value was determined.
B6C3F1 mice exposed to crotonaldehyde showed a rapid decrease in respiratory rate at the onset of exposure which sustained throughout the exposure period with little or no recovery. RD50 10 min = 4.88 (4.0 -6.3) ppm. Swiss-Webster mice usually exhibted a continuously decreasing respiratory rate during the exposure period, especially at higher exposure concentrations. RD50 10 min = 3.53 (2.88 -4.62) ppm.
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