tert-butyl {(1S)-1-[(2R)-oxiran-2-yl]-2-phenylethyl}carbamate

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

4 September - 8 December 1999

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: done under GLP and OECD method

Qualifier:

according to guideline

Guideline:

other: Particle size distribution was determined using a Coulter counter in accordance with OECD Guideline 110, Method A. Particle shape was determined visually using a microscope.

GLP compliance:

yes

Type of method:

microscopic examination

Remarks on result:

not determinable because of methodological limitations

Percentile:

other: This sample contains at least 2 populations of particles, therefore particles size distribution by a single Mass Mediuan Aerodynamic Diameter & Geometric Std. Dev. cannot be determined.(migrated from fields under 'Mass median diameter' as D50 percentile)

Remarks on result:

not determinable

No.:

#1

Size:

< 2 µm

Distribution:

10.1 %

No.:

#2

Size:

> 2 - < 199.3 µm

Distribution:

74.28 %

No.:

#3

Size:

> 199.3 µm

Distribution:

15.62 %

Conclusions:

This sample contains at least 2 populations of particles and therefore the particle size distribution by a single Mass Median Aerodynamic Diameter and geometric standard deviation cannot be determined. Examination of the data suggests that approximately 50% by mass of the particles may have have an aerodynamic diameter less than 10µm.

The particle size distribution is between 0.859 and 294.1µm equivalent spherical diameter with 10.1% by volume less than 2.0µm, 74.28% of particles between 2.0 and 199.3µm and 15.62% greater than 199.3µm. There is therefore considerable potential for inhalation of the dust of this material.

Description of key information

The sample contained at least 2 populations of particles and therefore the particle size distribution by a single Mass Median Aerodynamic Diameter and geometric standard deviation could be determined. Examination of the data suggested that approximately 50% of the particles may have had an aerodynamic diameter less than 10μm.

The particle size distribution was between 0.859 and 294.1µm equivalent spherical diameter with 10.1% by volume less than 2.0μm, 74.28% of particles between 2.0 and 199.3μm and 15.62% greater than 199.3μm. There is therefore potential for inhalation of the dust of this material.