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EC number: 230-386-8 | CAS number: 7085-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Wistar rats were administered the test material via a single injection into the abdominal cavity. Two doses were tested.
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- Mecoprop
- EC Number:
- 230-386-8
- EC Name:
- Mecoprop
- Cas Number:
- 7085-19-0
- Molecular formula:
- C10H11ClO3
- IUPAC Name:
- 2-(4-chloro-2-methylphenoxy)propanoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: About 12 Weeks
- Weight at study initiation: Mean Female 177 g (700 mg/kg), 169 g (200 mg/kg). Mean Male 170 g (700 mg/kg), 185 g (200 mg/kg)
- Fasting period before study: 16 hours
- Housing: Animals were housed in stainless steel wire mesh cages. 5 animals per cage.
- Water: Tap water ad libitum
- Acclimation period: At least one week
ENVIRONMENTAL CONDITIONS
- Temperature: 20-24 °C
- Humidity: 30-70
- Photoperiod: 12 h/12 h (6.00 - 18.00 hours/ 18.00 - 6.00 hours)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- TEST MATERIAL:
- Vehicle: 0.5 % aqueous carboxymethyl cellulose
- Amount applied: 10 mL/kg for each dose
- Concentration: 7 (700) and 2 % w/v (200 mg/kg).
MODE OF ADMINISTRATION:
- Single injection into the abdominal cavity - Doses:
- 200 and 700 mg/kg body weight
- No. of animals per sex per dose:
- 5 female and 5 male Wistar rats per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 15 Days
- Frequency of observations and weighing: Recording of signs several times on the day of administration and at least once each workday. Check for moribund and dead animals twice each workday and once on weekends and public holidays. Weight recorded at beginning of test, Day 2, Day 7 and Day 13.
- Necropsy of survivors performed: yes, withdrawal of feed 16 hours before sacrifice with CO2; then necropsy with gross-pathological assessment. All animals that died were necropsied as early as possible.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 700 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality was observed at dose 200 mg/kg bw for both male and female groups. At dose level 700 mg/kg bw all animals in both male and female groups were deceased after day 1.
- Clinical signs:
- At both dosages, there were observed clinical abnormalities which included dyspnea, apathy, staggering, spastic gait and poor general state. At the higher dosage level, more clinical abnormalities were observed including, abnormal positioning, atonia, missing pain reflex, narcotic-like state, ruffled fur and exsiccosis.
- Body weight:
- The mean body weights at 200 mg/kg bw increased during the observation period.
- Gross pathology:
- Animals that died: Abdomen: intra-abdominal collection of moderately clear liquids.
Sacrificed animals: Liver: intra-abdominal conglutinations; blunt margins. Spleen: serosa opalescent.
Any other information on results incl. tables
Mortality During the Study
Dose (mg/kg) | 700 | 200 | |
Males | |||
Number of Animals | 5 | 5 | |
Dead Animals After | 1 h | 0 | 0 |
1 d | 5 | 0 | |
2 d | 5 | 0 | |
7 d | 5 | 0 | |
14 d | 5 | 0 | |
Females | |||
Number of Animals | 5 | 5 | |
Dead Animals After | 1 h | 0 | 0 |
1 d | 5 | 0 | |
2 d | 5 | 0 | |
7 d | 5 | 0 | |
14 d | 5 | 0 |
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, the acute LD50 after a single intraperitoneal administration of test material in male and female rats was found to be > 200 < 700 mg/kg.
- Executive summary:
The acute toxicity of the test material after a single intraperitoneal administration was investigated, under GLP conditions.
5 male and 5 female Wistar rats per dose group were administered 200 and 700 mg/kg body weight by a single injection into the abdominal cavity. The test material was prepared with 0.5% aqueous carboxymethyl cellulose. Unspecific clinical symptoms were observed. Mortality occurred in the dosage of 700 mg/kg. Necropsy findings in animals that died: moderately clear liquids in the abdomen. In sacrificed animals: liver: intraabdominal conglutinations, blunt margins; spleen: serosa opalescent. In dosage 200 mg/kg no mortality occurred (LD0 = 200 mg/kg) and symptoms occurred at each dosage (ED0 = < 200 mg/kg).
Under the conditions of this study, the acute LD50 after a single intraperitoneal administration of test material in male and female rats was found to be > 200 < 700 mg/kg.
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