Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 230-386-8 | CAS number: 7085-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Mecoprop
- EC Number:
- 230-386-8
- EC Name:
- Mecoprop
- Cas Number:
- 7085-19-0
- Molecular formula:
- C10H11ClO3
- IUPAC Name:
- 2-(4-chloro-2-methylphenoxy)propanoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200 - 300 g
- Housing: Cages were made of stainless steel with wire mesh, type DKIII. Animals were housed 1 per cage.
- Water: Ad libitum tap water.
- Acclimation period: at least 1 week.
ENVIRONMENTAL CONDITIONS
- Temperature: 20 to 24 °C
- Humidity: 30 to 70 % relative humidity
- Photoperiod: 12 hours light/ 12 hours dark (06.00 - 18.00 hours/ 18.00 - 06.00 hours)
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Dorsal and dorso-lateral parts of the trunk; about 50 cm x 50 cm.
- The test suspension was applied in the morning. The test site was clipped at least 15 hours before application.
- Type of wrap if used: The application site was covered with a semi-occlusive dressing for 24 hours.
REMOVAL OF TEST SUBSTANCE
- Washing: 24 hours after application the dressing was removed and the application site was rinsed with warm water.
TEST MATERIAL
- 0.5 % aqueous carboxymethyl cellulose formed a 30 % w/v suspension with the test material.
- Amount(s) applied: for the 4 000 mg/kg treatment 13.3 mL/kg was applied. For the 2 000 mg/kg treatment 6.7 mL/kg was applied.
- Concentration: 30 % w/v
VEHICLE
- Aqueous formulation corresponds to the physiological medium. - Duration of exposure:
- 24 hours
- Doses:
- 2 000 and 4 000 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Scoring of skin findings: 30 - 60 minutes after removal of the semi-occlusive dressing and at least once weekly during the following observation period.
- Recording of signs and symptoms: Several times on the day of application, and at least once each work day. Checks for moribund and dead animals twice each work day and once on holidays.
- Necropsy of survivors performed: Yes. Food was withdrawn 16 hours before sacrifice with CO2, then necropsy with gross pathological examination was performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occurred.
- Clinical signs:
- other: No abnormalities were observed in any of the test animals. Erythema was observed.
- Gross pathology:
- No abnormalities were detected in the necropsy of sacrificed animals.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified in accordance with EU criteria.
- Conclusions:
- Under the conditions of this study, the acute dermal LD50 of the test material to rats was > 4 000 mg/kg.
- Executive summary:
The acute dermal toxicity of the test material was investigated in a study similar in design to OECD 402.
Ten male and female wistar rats were treated dermally with the test material at doses of 2 000 or 4 000 mg/kg for 24 hours. 30 - 60 minutes after removal of the semi-occlusive dressing and at least once weekly during the following observation period skin observations were performed. The animals were observed for 14 days before gross necropsy was performed.
No abnormalities were observed in any of the test animals but erythema was observed. No mortality occurred. Body weights increased during the observation period following test material application and no abnormalities were detected in the necropsy of sacrificed animals.
Under the conditions of this study, the acute dermal LD50 of the test material to rats was > 4 000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.