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EC number: 267-636-0 | CAS number: 67905-17-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Justification for type of information:
- data is from experimental reports
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FDA Guidelines(Federal Register Vol. 38, No. 187, S 27019, 1973)
- Principles of method if other than guideline:
- The mucous membrane compatibility of the test chemical was assessed in rabbits
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N-[4-[(9,10-dihydro-4-hydroxy-9,10-dioxo-1-anthryl)amino]phenyl]acetamide
- EC Number:
- 267-636-0
- EC Name:
- N-[4-[(9,10-dihydro-4-hydroxy-9,10-dioxo-1-anthryl)amino]phenyl]acetamide
- Cas Number:
- 67905-17-3
- Molecular formula:
- C22H16N2O4
- IUPAC Name:
- N-[4-[(9,10-dihydro-4-hydroxy-9,10-dioxo-1-anthryl)amino]phenyl]acetamide
- Test material form:
- solid
- Details on test material:
- - Name of test material : N-[4-[(9,10-dihydro-4-hydroxy-9,10-dioxo-1-anthryl)amino]phenyl]acetamide
- Molecular formula): C22H16N2O4
- Molecular weight : 372.378 g/mol
- Smiles notation : O=C(Nc1ccc(Nc2c3c(c(O)cc2)C(=O)c2c(cccc2)C3=O)cc1)C
- InChl: 1S/C22H16N2O4/c1-12(25)23-13-6-8-14(9-7-13)24-17-10-11-18(26)20-19(17)21(27)15-4-2-3-5-16(15)22(20)28/h2-11,24,26H,1H3,(H,23,25)
- Substance type: Organic
- Physical state: Powder
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: SPF-albino-Himalayan rabbit strain Hoe: HIMK (SPFWiga)
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 1.5-2.0 kg
- Housing:The animals were kept in individual cages
- Diet (e.g. ad libitum): compound feed ERKA 8300 of feed plants Robert Koch oHG / Hamm, ad libitum
- Water (e.g. ad libitum): water, ad libitum
IN-LIFE DATES: From: 5.9.1977 To: 8.9. 1977
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 100 mg of the powdered dye
- Duration of treatment / exposure:
- single application
- Observation period (in vivo):
- The assessment was performed 1,7,24,48 and 72 hours after the treatment with the help of a magnifying glass.
- Duration of post- treatment incubation (in vitro):
- no data available
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data available
- Time after start of exposure: no data available
SCORING SYSTEM:The ocular lesions were observed and scored according to the classification given in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, FDA, Austin, Texas, p. 51, 1975".
TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein: The assessment was performed 1,7,24,48 and 72 hours after the treatment with the help of a magnifying glass. After collecting the 24-hour report, all eyes were spooled with physiological saline solution. After 48 hours and 72 hours, after instillation of a drop of fluorescein sodium in the dilution 1: 10000 = 0.001%.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 7 hours
- Score:
- 16
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Irritant / corrosive response data:
- After application of the powdered dye, the highest irritation index of 16 was determined after 7 hours. According to the classification listed in the annex, the dye is therefore slightly irritating to the mucosa.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- After application of the test chemical, the highest irritation index of 16 was determined after 7 hours. According to the classification, the test chemicalwas therefore assessed to be slightly irritating to the eyes.
- Executive summary:
A test for mucous membrane compatibility of the test chemical was performed in rabbits. The test was performed according to the "1500.41 in Federal Register 38, No. 917, 27, 9, 173, P 27019" and FDA Guidelines.
6 SPF-albino-Himalayan rabbit strain Hoe: HIMK (SPFWiga) were used for the study. Single application of 100 mg of the powdered dye was instilled into the left conjunctival sac of 6 rabbits and the right eye remained untreated and served as control. The assessment for ocular lesions was performed 1, 7, 24, 48 and 72 hours after the treatment with the help of a magnifying glass. After collecting the 24-hour report, all eyes were spooled with physiological saline solution. After 48 hours and 72 hours, after instillation of a drop of fluorescein sodium in the dilution 1: 10000 = 0.001%. The ocular lesions were observed and scored according to the classification given in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, FDA, Austin, Texas, p. 51, 1975".
For the determination of the irritation index, the evaluations of the cornea (a), the iris (b) and the conjunctiva (c) are added for each rabbit at the respective reading time. The average value of the values of all rabbits is calculated at the corresponding reading time. The highest index determined at one of the reading times is used for grading.
After application of the test chemical, the highest irritation index of 16 was determined after 7 hours. According to the classification, the test chemicalwas therefore assessed to be slightly irritating to the eyes.
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