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EC number: 218-267-9 | CAS number: 2100-42-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976-11-11 to 1977-01-19
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well documented study report which meets basic scientific principles. Study was conducted prior to GLP and OECD guideline implementation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Company guiedeline previous to OECD guideline implementation that is similar to OECD 401.
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The liquid test substance was diluted to several concentrations using sesame oil. Each dilution was administered once to female SPF-Wistar rats. The rats were obtained from in-house breeding and had a mean body weight of 109g (ranging from 100-123g). Since pretests didn't show sex-linked differences in sensitivity only female rats were used. 10 rats were used per dose. 16hrs prior to administration food was withdrawn, 2hrs after adminstration food was made available again. The observation period after administration was 14d. During this time all animals had ad libitum access to food (Altromina 1324, Company Altromin GmbH, Lage/Lippe) and tap water. Housing of animals was done in plastic cages with wood shavings and one animal per cage. Lethally intoxicated animals were dissected and macroscopically evaluated. Surviving animals were narcotized and killed at the end of the observational period. Additionally, they were dissected and macroscopically evaluated.
- GLP compliance:
- no
- Remarks:
- - Performed prior to GLP implementation
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-chloro-2,5-dimethoxybenzene
- EC Number:
- 218-267-9
- EC Name:
- 1-chloro-2,5-dimethoxybenzene
- Cas Number:
- 2100-42-7
- Molecular formula:
- C8H9ClO2
- IUPAC Name:
- 2-chloro-1,4-dimethoxybenzene
- Details on test material:
- - Name of test material (as cited in study report): CME = Chlorhydrochinondimethyläther (2-Chlor-1,4-dimethoxybenzol)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- - Rats were obtained from in-house breeding and a mean body weight of 109g (ranging from 100-123g)
- Pretests ruled out any sex-linked differences in sensitivity --> only female rats were used
- 10 rats were used per dose
- 16hrs prior to administration food was withdrawn
- 2hrs after adminstration food was made available again
- Observation period after administration was 14d
- During this time all animals had ad libitum access to food (Altromina 1324, Company Altromin GmbH, Lage/Lippe) and tap water
- Housing of animals was done in plastic cages with wood shavings.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 4% - Doses:
- 630, 1000, 1600, 2000mg per kg bw
- No. of animals per sex per dose:
- 10 female Wistar rats per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Frequency of weighing: once a week - Statistics:
- LD50 were calculated using Probit models (according to Linder and Weber), confidence intervals were calculated according to Cavalli-Sforza.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 659 mg/kg bw
- 95% CL:
- 1 503 - 1 830
- Mortality:
- 630 mg/kg bw: 0 out of 10
1000 mg/kg bw: 0 out of 10
1600 mg/kg bw: 4 out of 10
2000 mg/kg bw: 9 out of 10 - Clinical signs:
- other: Lethally intoxicated animals showed: ataxic gait, squatting posture, clear colored lacrimation, closed eyes, lateral or prone position, narcosis-like condition
- Gross pathology:
- No abnormal findings
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- LD50: 1659mg/kg bw
- Executive summary:
Testing for acute oral toxicity resulted in a LD50 of 1659mg/kg body weight.
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