Registration Dossier
Registration Dossier
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EC number: 267-041-6 | CAS number: 67763-18-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on microorganisms
Key value for chemical safety assessment
Additional information
Since studies on the toxicity to activated sludge microorganisms are not available a ready biodegradability study is used to derive a NOEC for the toxicity to aquatic microorganisms. If a compound degrades well in a ready biodegradability test, or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2016). A substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on [oxygen demand (BOD/ThOD) or CO2 evolution (CO2/ThCO2)] occurred within 14 days (OECD guideline 301). For the target substance Diisooctadecyl malate (CAS 67763-18-2) a biodegradation test according to OECD guideline 301F is available (Simon, 2015). The test includes a toxicity control, which contains 100 mg/L of Diisooctadecyl malate and 100 mg/L of the reference material (sodium benzoate). The toxicity control attained 37% degradation after 14 days of incubation (25% trigger was reached). Hence, the substance is not toxic to aquatic microorganisms in the toxicity control and the test item concentration of 100 mg/L can be used as NOEC.
Based on the available result from the toxicity control of the biodegradation study, it can be concluded that Diisooctadecyl malate will not affect the growth of microorganisms.
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