Registration Dossier
Registration Dossier
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EC number: 267-041-6 | CAS number: 67763-18-2
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on fish up to the limit of water solubility
Key value for chemical safety assessment
Additional information
Data on the acute toxicity of Diisooctadecyl malate (CAS 67763-18-2) to fish is not available. The assessment was therefore based on a study conducted with the structurally similar substance Diisodecyl Azelate (CAS 28472-97-1) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification section 13.
The acute toxicity of Diisodecyl Azelate (CAS 28472-97-1) to fish was tested in a study according to OECD 203 (Hansonis-Jouleh, 1993). The test fish (Leuciscus idus melanotus) were exposed in a limit test to a test substance concentration of 10000 mg/L under static test conditions. A LC50 (96 h) > 10 g/L (nominal) was determined indicating no effects.
Based on the available result from one structurally related source substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that Diisooctadecyl malate is not acutely toxic to fish up to the limit of water solubility.
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