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Diss Factsheets
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EC number: 242-171-6 | CAS number: 18293-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 30.11.1983 to 14.12.1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Read across to the registered substance is considered to be scientifically justified. Both the original study and the read across are reliability 2. The study was conducted according to an appropriate OECD test guideline, with acceptable restrictions. The restrictions were lack of some protocol and results detail. No information on test substance purity.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- no analytical verification of concentration, parts of protocol and results missing from report.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Trimethoxy(2-methylpropyl)silane
- EC Number:
- 242-272-5
- EC Name:
- Trimethoxy(2-methylpropyl)silane
- Cas Number:
- 18395-30-7
- IUPAC Name:
- isobutyl(trimethoxy)silane
- Details on test material:
- - Name of test material (as cited in study report): Dow Corning X1-2204 (isobutyl(trimethoxy)silane)
- Substance type: Alkoxysilane
- Physical state: Liquid
- Analytical purity: No data
- Purity test date: No data
- Lot/batch No.: BNO93006
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratory
- Age at study initiation: No data
- Weight at study initiation: 210 ±35 g
- Fasting period before study: No
- Housing: Stainless steel cages (cages designed to permanently house the animals during exposure and observation period.
- Diet (e.g. ad libitum): Ad libitum (except during actual exposure)
- Water (e.g. ad libitum): Ad libitum (except during actual exposure)
- Acclimation period: Seven days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ±2
- Humidity (%): 30-70
- Air changes (per hr): 12-15
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: From: 30.11.1983 to 14.12.1983
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 450 litre stainless steel and glass exposure chambers under dynamic conditions.
- Method of holding animals in test chamber: cage only
- Source and rate of air: The chamber air was supplied by a heating, ventilation and air conditioning (HVAC) system that was separate from the general laboratory system. The intake air was filtered (HEPA and charcoal), and temperature and humidity were controlled.
- Treatment of exhaust air: No data
- Temperature, humidity, pressure in air chamber: 22 ±2oC, 30-70%, no pressure information.
TEST ATMOSPHERE
- Brief description of analytical method used: No details in report.
- Samples taken from breathing zone: No data - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- ca. 4 h
- Concentrations:
- 1525 ppm (Based on rangefinding study) (report states that this is approximately 11 mg/l)
- No. of animals per sex per dose:
- Five
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were weighed on days 7 and 14 of the observation period. They were observed frequently during the exposure period and daily during the week days of the observation period.
- Necropsy of survivors performed: yes, a complete gross pathological examination was performed on all major tissues and organs. Special attention was paid to the lungs and trachea. - Statistics:
- None
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 525 ppm
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Equivalent to 11 mg/l. There were no deaths within the 14 days post-exposure period.
- Mortality:
- There were no deaths.
- Clinical signs:
- other: The experimental animals appeared lethargic and unresponsive during the exposure period. However, on removal from the chamber, the animals quickly recovered and did not show any stress or signs of toxicity during the 14-day observation period. The control
- Body weight:
- There were no effects on body weights in control and test animals.
- Gross pathology:
- No exposure-related gross pathological alterations were observed in any of the organs or tissues.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute inhalation study (that was comparable to OECD 403 and to GLP (reliability score 2), the LC50 for Dow Corning X1-2204 (isobutyl(trimethoxy)silane) was greater than 1525 ppm (11 mg/l) (the only concentration tested) in Sprague-Dawley rats. The animals were lethargic and unresponsive during the exposure period. However, on removal from the chamber, the animals quickly recovered and did not show any stress or signs of toxicity during the 14-day observation period.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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