Registration Dossier
Registration Dossier
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EC number: 242-171-6 | CAS number: 18293-82-8
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
Water solubility [isobutyl(dimethoxy)methylsilane]: 510 mg/l at 20-25°C (QSAR)
Water solubility [isobutyl(methyl)silanediol]: 8.1E+04 mg/l at 20-25°C (QSAR)
Water solubility [methanol]: miscible (measured)
Key value for chemical safety assessment
- Water solubility:
- 510 mg/L
- at the temperature of:
- 20 °C
Additional information
The requirement to test the substance for water solubility is waived on the basis that it hydrolyses rapidly to isobutyl(methyl)silanediol and methanol.
Isobutyl(dimethoxy)methylsilane has a calculated water solubility of 510 mg/l at 20-25°C.
The silanol hydrolysis product, isobutyl(methyl)silanediol, may undergo condensation reactions in solution; these become important above approximately 100 mg/l and can limit the concentration dissolved in water. For details, see the overall physicochemical properties discussion.
Isobutyl(methyl)silanediol is very hydrophilic and hence the calculated solubility is 8.1E+04 mg/l at 20-25°C using a QSAR method. However, the saturation concentration of isobutyl(methyl)silanediol in water is limited by condensation reactions rather than lack of true solubility, as discussed above. The prediction is however considered valid for use in calculation of the Henry’s Law Constant and for environmental exposure modelling and toxicokinetics modelling because it is considered to adequately describe the hydrophilicity of the substance and hence the partitioning behaviour.
Methanol is miscible in water at 20°C based on experimental data (OECD 2004a).
OECD (2004): SIDS Initial Assessment Report for SIAM 19, Berlin, Germany, 18-20 October 2004, Methanol, CAS 67-56-1
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