2,4,6-trichloro-1,3,5-triazine

Endpoint summary

Description of key information

Oral:  LD50: 315 mg/kg bw(males) and 327 mg/kg bw (females) (rats) 
Inhalation:  4 h-LC50: 25  mg/m³ air (rats) and 2 h-LC50: 10  mg/m³ air (mice)
Dermal: no deaths and no evidence of resorption or systemic toxicity, even at doses up to 10 g/kg. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

LD50

Value:

315 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Dose descriptor:

LC50

Value:

10 mg/m³

Acute toxicity: via dermal route

Endpoint conclusion

Dose descriptor:

discriminating dose

Value:

10 000 mg/kg bw

Additional information

In accordance to column 2 of REACH Annex VIII, the study of acute toxicity oral and dermal does not need to be conducted since the substance is classified as corrosive to the skin. Nevertheless, the results of an acute toxicity study after single oral administration of cyanuric chloride have been stated in rats : oral LD50 were 315 mg/kg (males) and 327 mg/kg (females).

Also, in an acute exposure study, when cyanuric chloride was applied to the skin of rabbits, it produced severe skin irritation,but no deaths and no evidence of resorption or systemic toxicity, even at doses up to 10 g/kg.

The acute exposure in two inhalation studies with the dust (cyanuric chloride) has shown that 4h-LC50 is rats is 25 mg/m³ and

2h-LC50 is mice is 10 mg/m³, with the threshold for CNS disturbances being 0.6 mg/m³.

Justification for classification or non-classification

Harmonized Classification and labelling:

T+ R26 ; Xn R 22

GHS:

Acute toxicity inhalation Cat. 2
Acute toxicity oral Cat. 4