Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-851-5 | CAS number: 100-42-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species, other
- Type of information:
- other: review data
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A mean log value based on different studies has been caculated. By using the Kow value and the equation for BCF from the TGD a BCF is derived.
- GLP compliance:
- no
- Radiolabelling:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: calculated from log Kow
- Route of exposure:
- other: calculated BCF
- Test type:
- other: calculated BCF
- Water / sediment media type:
- not specified
- Nominal and measured concentrations:
- calculated BCF from different studies
- Reference substance (positive control):
- not required
- Details on estimation of bioconcentration:
- A mean log value based on different studies has been caculated. By using the Kow value and the equation for BCF from the TGD a BCF is derived.
- Type:
- BCF
- Value:
- 74
- Basis:
- other: not specified
- Calculation basis:
- other: Kow value and the equation for BCF from the TGD were used to derive the BCF
- Remarks on result:
- other: calculated
- Validity criteria fulfilled:
- not applicable
- Executive summary:
Styrene was tested for bioaccumulation. The BCF was determined to be 74.
Reference
An experimental study which indicated that styrene did not bioconcentrate to the levels expected from its Kow value is not considered valid. However, no further testing is required for the risk assessment as available data from other substances are sufficient for this purpose. In the risk assessment a bioconcentration factor of 74 is used, as predicted from the partition coefficient. To derive this BCF three measured values for the octanol-water partition coefficient (as log Kow) were used, these are 2.95 (Hansch and Leo, 1979), 2.96 (BASF, 1987) and 3.16 (Banerjee et al., 1980). The mean log value from these studies has been used in the environmental modelling in this risk assessment (this is equivalent to taking the geometric mean of the actual measurements). This gives a value of 3.02. On the basis of the balance of the information available it is concluded that styrene will not accumulate in aquatic organisms and that R53 is therefore not appropriate. The Commission
working group on the Classification and Labelling of Dangerous Substances at their meeting on 15-17 September 1999, agreed not to classify styrene for environmental effects.
Description of key information
Significant accumulation in organisms is not to be expected
The value for log n-octanol-water partition coefficient (log Kow), which is considered a good predictor for bioconcentration, is approximately three. Since an experimental study showing low bioaccumulation of styrene is considered not valid, the BCF was predicted using log Kow and the equation from the TGD, giving a value of 74.
Key value for chemical safety assessment
- BCF (aquatic species):
- 74 dimensionless
Additional information
A QSAR was performed as well using the BCF baseline. The BCF was predicted to be between 1.714 and 2.016 l/kg. These values suggests that the compound probably does not accumulate appreciably in aquatic organisms. Moreover, because styrene is probably metabolized and excreted, bioaccumulation is unlikely. This is also supported by the fact that analogue substances, such as toluene, xylene and ethylbenzene do not accumulate to any great degree in aquatic organisms.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.