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Diss Factsheets
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EC number: 203-419-9 | CAS number: 106-65-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- Study pre-dates test guidelines
- Principles of method if other than guideline:
- "Standard" LD50 test
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP regulations
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl succinate
- EC Number:
- 203-419-9
- EC Name:
- Dimethyl succinate
- Cas Number:
- 106-65-0
- Molecular formula:
- C6H10O4
- IUPAC Name:
- dimethyl succinate
- Details on test material:
- - Name of test material (as cited in study report): Bernsteinsaurerdimethylester
- Lot/batch No.: E438
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 82 - 115 g
- Fasting period before study: 16 hours
- Diet (e.g. ad libitum): Altromin R rat diet, ad-libitum except for a 16 hour fast prior to dosing and approximately 2 hours after dosing
- Water (e.g. ad libitum): Ad-libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
IN-LIFE DATES: From: Not reported To: Not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- vegetable oil
- Remarks:
- sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25%
- Justification for choice of vehicle: Solubility miscibility
- Lot/batch no. (if required): Not reported
- Purity: Not reported - Doses:
- 4000, 6300, 8000, 10000 and 15000 mg/kg
- No. of animals per sex per dose:
- 10 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations - Frequently following dosing followed by at least daily. Weighing - Weekly
- Necropsy of survivors performed: Not reported - Statistics:
- Probit analysis
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 6 892 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 6 256 - 7 592
- Mortality:
- 4000 mg/kg - 0 / 10 (0%)
6300 mg/kg - 3 /10 (30%)
8000 mg/kg - 8 / 10 (80%)
10000 mg/kg - 10 / 10 (100%)
15000 mg/kg - 10 / 10 (100%)
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The median lethal dose (LD50) of the substance following a single oral dose was determined to be 6892 mg/kg body weight
- Executive summary:
The test susbtance was administered as a single dose, by gavage, to groups of 10 female rats. Animals were observed for 14 days following dosing for mortality and clinical signs. The incidence of mortality relative to dose was used to calculate the median lethal dose by probit analysis.
The median lethal dose (LD50) of the substance following a single oral dose was determined to be 6892 mg/kg body weight
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