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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption, other
Remarks:
in silico
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Study period:
December 02, 2013
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
See the attached justification.

Data source

Referenceopen allclose all

Reference Type:
other: software
Title:
Unnamed
Year:
2011
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Guideline:
other: ECHA Guidance on information requirements and chemical safety assessment - Chapter R.06: QSARs and grouping of chemicals
Principles of method if other than guideline:
See the justification for type of information.

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl succinate
EC Number:
203-419-9
EC Name:
Dimethyl succinate
Cas Number:
106-65-0
Molecular formula:
C6H10O4
IUPAC Name:
dimethyl succinate

Results and discussion

Percutaneous absorption
Time point:
1 h
Dose:
Deposition dose: 5347 mg
Parameter:
rate
Absorption:
<= 0.061 mg cm-2 h-1

Any other information on results incl. tables

DATA INPUT

Substance

EC name: dimethyl succinate

CAS number: 106-65-0

Molecular weight: 146.14

Temperature: 25 °C

Vapour Pressure: 23.5 Pa (experimental data)

Water solubility: 122900 mg/L (experimental data)

Log Kow (skin, pH= 5.5): 0.33 (experimental data)

Density: 1113.9 mg/cm3 (extrapolated from experimental data)

 

Scenario parameters

Instantaneous deposition

Deposition dose*: 5347 mg

Affected skin area**: 1000 cm2

Thickness of stagnant air***: 1 cm

 

Timing parameters

Start deposition: 0 hr

End time observation: 4 hr

 

Report parameters

Calculationintervals/hours: 6000

Report intervals/hours: 600

 

*Approximately 2 mL of a liquid having a viscosity similar to water will practically wet the palms of two hands(ca. 420cm2).So 4.8 mL will wet all the skin surface of both hands. Ii is reasonably expected more liquid will be

excess and wash/fall off.

 

**Estimated skin surface of two hands of an adult.

 

***Nude skin.

 

RESULTS

Deposition: Instantaneous

Tot. Deposition: 5347 mg

 

Fraction absorbed: 8.8%

Amount absorbed: 472.0 mg

Lag time stratum corneum:40.0 min.

 

Max. derm. abs.: 0.0613 mg/cm2/hr

Max. derm. abs. for 2000 cm2in 1 hour (from liquid): 123 mg

 

Dermal/Respiratory uptake ratio (from airborne vapour): R= 0.7252

 

R= RX/X

RX: total dermal absorption by dermal exposure to airborne vapour

X:  total inhalation absorption from airborne vapour

 

Assuming that Fully Respiratory Protection provides 100% efficiency:

Protection from respirator= 100*X/(RX+X)= 100/(R+1)= 100/1.725= 58.0% protection against overexposure to the substance in the form of vapour due to dermal vapour absorption over whole body surface.

Applicant's summary and conclusion

Conclusions:
The dermal absorption of dimethyl succinate leads to the following results, obtained using the SkinPerm v1.15 model according to the input data:

Fraction absorbed: 8.8%
Amount absorbed: 472.0 mg
Lag time stratum corneum: 40.0 min.

Max. derm. abs.: 0.0613 mg/cm2/hr
Max. derm. abs. for 2000 cm2 in 1 hour (from liquid): 123 mg

Dermal/Respiratory uptake ratio (from airborne vapour): R= 0.725
Executive summary:

In-silico evaluation of dermal absorption indicates that after one hour only a small amount of deposited substance is absorbed within viable epidermis and therefore enter in systemic circulation.