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Diss Factsheets
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EC number: 201-180-5 | CAS number: 79-14-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
- Endpoint:
- sediment toxicity: short-term
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliance
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OSPAR 1995: Protocols on Methods for the Testing of Chemicals Used in the Offshore Oil Industry, Part A: Sediment Bioassay Using an Amphipod Corophium sp. Pg 3 – 22
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Glycollic acid
- EC Number:
- 201-180-5
- EC Name:
- Glycollic acid
- Cas Number:
- 79-14-1
- Molecular formula:
- C2H4O3
- IUPAC Name:
- 2-hydroxyacetic acid
- Details on test material:
- glycolic acid 70% solution
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test substrate
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Corophium volutator
Study design
- Study type:
- laboratory study
- Test type:
- static
- Water media type:
- saltwater
- Type of sediment:
- natural sediment
- Limit test:
- no
Exposure duration
- Duration:
- 10 d
- Exposure phase:
- total exposure duration
Test conditions
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 10 d
- Dose descriptor:
- LC50
- Effect conc.:
- 916 mg/kg sediment dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
Any other information on results incl. tables
Mortality was 9% in the controls at the end of the study. Mortality in test vessels was corrected for control mortality using Abbot’s correction.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- An assessment of the solid-phase (sediment ) toxicity (10-day LC50) of glycolic acid 70% solution was made using the sediment-dweling amphipod, Corophium volutator (Pallas). A 10-day LC50 of 916 mg/kg dry sediment weight (equivalent to 641mg/kg dry sediment weight) was found with 95% confidence intervals of 512 - 1587 mg/kg dry sediment weight (equivalent to 358.4 – 1111 mg/kg dry sediment weight).
- Executive summary:
The acute toxicity of glycolic acid 70% solution to the marine sediment reworker Corophium volutator under static test conditions, was investigated according to the OSPAR 1995: Protocols on Methods for the Testing of Chemicals Used in the Offshore Oil Industry, Part A: Sediment Bioassay Using an Amphipod Corophium sp. Pg 3 – 22. Based on nominal exposure concentrations the 10-day LC50 value for C. volutator exposed to glycolic acid 70% solution was 916 mg/kg sediment dry weight (equivalent to 641 mg/kg sediment dry weight).
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