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EC number: 201-058-1 | CAS number: 77-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
All studies available for repeated dose toxicity are considered to be of low reliability (RL 3 or RL 4), and no NOAEL could be derived. However, a short communation of citations found and evaluated during the literature search is made available in section 13 of this technical dossier.
According to the EU risk assessment, 2002 the following on repeated dose toxicity, inhalation is stated:
In a carcinogenicity study, rats and mice were exposed to 2.6 mg/m3 DMS (6 hr/d, 2d/wk) or 10.5 mg/m3 (once every two weeks) or a sublethal dose of 175.35 mg/m3 (every 3 months) for about 15 months (Schlögel, 1972: see 7.5.3). It is considered not suitable for evaluation as repeated dose study according to the guidelines, because no haematology, no clinical biochemistry and very limited histopathological examinations were performed.
After exposure, the behaviour of exposed animals was affected: animals were apathic, eyes were half-open or closed and breathing problems were apparent. These effects clearly showed a concentration dependency in severity, total duration and time of onset. Body weight gain in DMS-exposed rats and mice was distinctly lower than in control animals. In general, survival in groups exposed to DMS was lower than in controls, but the mean survival time varied considerably between the various groups. A remarkable finding was the very low survival time in male and female rats of the 2.6 mg/m3 group which was distinctly lower than the survival time in rats of the control or the 10.5 mg/m3 group. The same phenomenon was seen in mice although less pronounced. The lower survival time in the 2.6 mg/m3 group is probably due to the initial high exposure regimen applied to this exposure group. An increase in the incidence of inflammation of the lungs was reported in DMS-exposed animals in all species. Bronchiopneumonia occurred to about the same degree in control and DMS exposed animals.
Justification for classification or non-classification
The available data are considered as insufficient to derive a NOAEL for repeated exposure. Amongst others the study of Schlögel is considered not suitable for evaluation as repeated dose study according to the guidelines, because no haematology, no clinical biochemistry and very limited histopathological examinations were performed. The data submitted do not fulfil the basic requirements for classification and labelling of the substance in accordance to regulation (EC) 1272/2008. However, according to the EU risk assessment report, 2002 it is noted that the carcinogenic activity of DMS, i.e., the cancer incidence per mg/m3 under occupational conditions of exposure, points to very low acceptable exposure levels with regard to the carcinogenic effects. It is expected that compliance to these low exposure levels will prevent effects other than carcinogenic effects to occur.
Since the substance fulfills the requirements under regulation (EC) 1907/2006 article 18(4) a-f it is not foreseen to initiate a further repeated dose toxicity study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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