Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 281-192-5 | CAS number: 83897-84-1
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Test conducted according to the protocol for "Single Cell Gel/Comet Assay: Guidelines for In Vitro and In Vivo Genetic Toxicology Testing" Tice et al. (2000), but no metabolic activation system was used. With respect to the calcium fraction in CaCO3.MgO, the test substance Ca(OH)2 can be considered as equivalent. Therefore, the results of the current study are supportive for lack of genotoxic effects of calcium released from CaCO3.MgO (calcined dolomite). This information therefore fulfils Annex XI, point 1.5 of Regulation (EC) No 1907/2006.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Genotoxicity of antimicrobial endodontic compounds by single cell gel (comet) assay in chinese hamster ovary (CHO) cells
- Author:
- Ribeiro, D.A.; et al.
- Year:
- 2 005
- Bibliographic source:
- Oral. Surg. Oral. Med. Oral Pathol Oral Radiol. Endod. 99: 637-640
Materials and methods
- Type of study / information:
- In vitro single cell gel electophoresis, mammalian cells
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: the protocol for "Single Cell Gel/Comet Assay: Guidelines for In Vitro and In Vivo Genetic Toxicology Testing" Tice et al. (2000)
- Deviations:
- yes
- Remarks:
- no metabolic activation was used
- GLP compliance:
- no
Test material
- Reference substance name:
- Calcium dihydroxide
- EC Number:
- 215-137-3
- EC Name:
- Calcium dihydroxide
- Cas Number:
- 1305-62-0
- IUPAC Name:
- calcium dihydroxide
- Details on test material:
- - Name of test material (as cited in study report): Calcium hydroxide
- Physical state: solid
No further details are given.
Constituent 1
Results and discussion
Any other information on results incl. tables
Calcium hydroxide did not contribute to DNA damage at all concentrations tested.
Applicant's summary and conclusion
- Conclusions:
- There is no indication of any potential for DNA damage of calcium hydroxide in this study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
