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EC number: 200-913-6 | CAS number: 75-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Type of method:
- static method
- Key result
- Temp.:
- 293.15 K
- Vapour pressure:
- 7.09 kPa
- Remarks on result:
- other: (20°C)
- Conclusions:
- The substance 2,2,2-Trifluoroethanol (TFE) is considered as a volatile organic compound (V.O.C.) according to Directive 1999/13/EC criteria.
- Executive summary:
Measurements of eight vapor pressures of 2,2,2-trifluoroethanol, for temperatures between 20 and 90°C, were conducted using the static method. This experiment provides a value of 7.09 kPa at 20°C. Results were fitted to a Wagner-type equation.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Type of method:
- static method
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 7 023 Pa
- Conclusions:
- The substance 2,2,2-Trifluoroethanol (TFE) is considered as a volatile organic compound (V.O.C.) according to Directive 1999/13/EC criteria.
- Executive summary:
Measurements of sixteen vapor pressures of 2,2,2-trifluoroethanol, for temperatures between -0.40 and 25.40°C, were conducted using an apparatus that can be related to the static method. Results were fitted to a linear regression equation, which provides an interpolated value of 7023 Pa at 20°C.
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- The measurements were conducted according to the static method, however, the results are out of the recommended range of the method, according to the guideline; moreover no result is provided at ambient temperature.
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Type of method:
- static method
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 7.1 kPa
- Remarks on result:
- other: extrapolated by Wagner-type equation
- Temp.:
- 20 °C
- Vapour pressure:
- 11.1 kPa
- Remarks on result:
- other: extrapolated by linear regression
- Conclusions:
- The substance 2,2,2-Trifluoroethanol (TFE) is considered as a volatile organic compound (V.O.C.) according to Directive 1999/13/EC criteria.
- Executive summary:
Forty-three vapor pressures were measured for temperatures from the boiling point (ca 80°C) to the critical point (226°C) of 2,2,2-trifluoroethanol. These data were obtained with a phase-equilibrium cell designed for precise static measurements at pressures up to 20 MPa. Results were fitted to a Wagner-type equation. This relashionship provides an extrapolated value of 7.1 kPa at 20°C. Considering a linear regression as recommended by the guidelines, a consistent result of 11.1 kPa at 20°C is obtained.
- Endpoint:
- vapour pressure
- Type of information:
- not specified
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Temp.:
- 20 °C
- Vapour pressure:
- 72 mBar
- Conclusions:
- The substance 2,2,2-Trifluoroethanol (TFE) is considered as a volatile organic compound (V.O.C.) according to Directive 1999/13/EC criteria.
- Executive summary:
The german GESTIS database provides information on hazardous substances, including some physico-chemical properties; a Vapour Pressure of 7200 Pa at 20°C is cited for the substance 2,2,2-Trifluoroethanol.
Referenceopen allclose all
The experimental vapor pressure data for TFE in the range 293.15 to 363.15 K are shown in the following table:
T (K) | P (kPa) |
293,15 | 7,09 |
303,15 | 12,74 |
313,15 | 21,70 |
323,15 | 35,60 |
333,15 | 56,50 |
343,15 | 86,54 |
353,15 | 128,51 |
363,15 | 186,02 |
To utilize the data in a wide temperature range, the existing vapor pressure data (Sauermann et al., 1993) in the range 348-443 K combined with the results in the table were fitted to a Wagner-type equation:
ln (P/Pc) = (Tc / T) x (-9.13279X + 3.07541X1.5 -8.42048X2.5 + 3.49555X5)
where Pc = 4.87 MPa and Tc = 499.29 K are the critical pressure
(Sauermann et al., 1993) and temperature (Baehr et al., 1989), and X = 1
- (T/Tc).
The root mean squared deviation is 0.16%.
To compare the present experimental data with the literature, the deviation has been calculated. For the literature data examined in the publication, the maximum mean deviation was 2.7%.
The table below shows the vapor pressures as a function of temperature determined from two samples freshly distilled into the system.
Temperature (°C) | Vapor pressure (mm) |
-0,40 | 13,55 |
0,30 | 13,80 |
2,25 | 16,05 |
4,10 | 18,55 |
5,85 | 21,00 |
7,55 | 23,55 |
8,75 | 25,60 |
9,30 | 26,50 |
11,10 | 29,90 |
12,40 | 32,85 |
15,00 | 38,65 |
16,80 | 43,15 |
19,80 | 52,05 |
20,60 | 54,40 |
23,10 | 63,35 |
25,40 | 72,50 |
The best straight line through the points of a plot of log (pressure) versus reciprocal temperature was computed by the method of least squares, the data being fitted to the equation:
log P = 9.651 - 2325/T
where P = vapor pressure in mm, and T is absolute temperature.
The probable error of estimate of a calculated log P is 2.92 10-3.
Forty-three experimental values of the vapor pressure are given in the table below:
T (K) | p (kPa) | T (K) | p (kPa) | T (K) | p (kPa) | T (K) | p (kPa) |
353,15 | 128,96 | 413,15 | 833,19 | 463,15 | 2520,35 | 495,15 | 4521,7 |
353,15 | 128,98 | 413,15 | 833,34 | 463,15 | 2520,51 | 495,15 | 4520,9 |
363,15 | 186,09 | 423,15 | 1066,57 | 473,15 | 3047,8 | 495,15 | 4520,8 |
363,15 | 186,07 | 423,15 | 1066,60 | 473,15 | 3047,6 | 497,15 | 4681,4 |
373,15 | 261,82 | 433,15 | 1345,75 | 478,15 | 3341,6 | 497,15 | 4681,6 |
383,15 | 360,01 | 433,15 | 1345,77 | 478,15 | 3341,6 | 497,15 | 4681,2 |
383,15 | 360,16 | 443,15 | 1676,63 | 483,15 | 3657,6 | 498,15 | 4764,1 |
393,15 | 484,95 | 443,15 | 1676,84 | 483,15 | 3657,7 | 498,15 | 4764,5 |
393,15 | 485,02 | 453,15 | 2065,92 | 488,15 | 3998,0 | 499,15 | 4849,1 |
403,15 | 641,16 | 453,15 | 2066,09 | 488,15 | 3998,1 | 499,15 | 4849,1 |
403,15 | 641,26 | 493,15 | 4365,2 | ||||
493,15 | 4365,4 |
In the publication, the data were fitted to a vapor pressure Wagner-type equation with four coefficients, taking into account the critical properties. The average and maximum of the relative deviations are 0.077x10-3and 0.240x10-3, respectively.
As recommended by the guidelines (OECD104/EC A4), the equation of log p = f (1/T) was recalculated from the above data, and found to be:
log p = -1878.7/T + 10.45 (R2= 0.999)
The values at 20°C (293.15 K) were extrapolated from these equations.
Description of key information
Experimental results: 7.09 kPa at 20°C (measured), 7023 Pa at 20°C (interpolated), 7.1 kPa at 20°C (extrapolated)
Literature data: 7200 Pa at 20°C (Gestis database)
Key value for chemical safety assessment
- Vapour pressure:
- 7.1 kPa
- at the temperature of:
- 20 °C
Additional information
Three publications describing experimental measurements with the static method, and covering temperatures between -0.40 and 226°C are presented.
Chaudhari 1995 is considered as the key study, as information is sufficient to ensure reliability, and the vapour pressure was determined at 20°C exactly (7.09 kPa).
Meeks 1967 is acceptable despite short description, and the reference temperature is within the measuring range.
Baehr 1989 conducted experimentation at elevated temperatures, above the boiling point, and vapour pressure results are out of the range for the method, based on the guideline recommendations. Nevertheless, when the data are fitted to a Wagner-type equation, the extrapolated value at 20°C is fully consistent with the two previous references (7.1 kPa). If calculated from the standard linear regression of log P = f(1/T), the extrapolation is in the same magnitude of order (11.1 kPa), but it will not be taken into account for the key value, as considered less precise (compared to other experimental results, and due to the change in physical state).
Supporting literature data from the german Gestis database is also consistent with the above experimental data: 7200 Pa at 20°C.
The retained key value will be the arimethic mean of the four results presented above.
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