Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-765-4 | CAS number: 623-03-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: sediment simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: no guideline reported
- Principles of method if other than guideline:
- Sediment samples (solid content: 69 g/L) were incubated at 25 °C under nitrogen atmosphere with 1.4 mg/L = 0.01 mmol/L. In a second experiment with sediment samples having a solid content of 93 mg/l, 4-chlorobenzonitrile was incubated at an initial concentration of 0.14 mg/L.
In a third experiment sediment extracts were prepared by extracting sediment samples with 20 % glycerin. The protein fraction was precipitated using gel chromatography and ion-exchange chromatography. The benzonitrile metabolising portein fraction was used in the degradation experiments with 4-chlorobenzonitrile at a concentration of 1.4 mg/L = 0.01 mmol/L. - GLP compliance:
- not specified
- Radiolabelling:
- no
- Oxygen conditions:
- anaerobic
- Inoculum or test system:
- natural sediment
- Duration of test (contact time):
- >= 40 d
- Initial conc.:
- 1.4 mg/L
- Based on:
- test mat.
- % Degr.:
- 45
- Parameter:
- test mat. analysis
- Sampling time:
- 20 d
- Remarks on result:
- other: in sediment samples, solid content: 69 mg/L; no lag phase; first order reaction
- % Degr.:
- 70
- Parameter:
- test mat. analysis
- Sampling time:
- 40 d
- Remarks on result:
- other: in sediment samples, solid content: 69 mg/L; no lag phase; first order reaction
- % Degr.:
- 100
- Parameter:
- test mat. analysis
- Sampling time:
- 8 d
- Remarks on result:
- other: in sediment extracts; zero order reaction
- Compartment:
- sediment
- DT50:
- 19 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: in sediment samples, solid content: 93 mg/L
- Transformation products:
- no
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- In sediment samples with 69 mg solids/L 70 % of the initial test substance has been degraded after 40 days. The degradation experiment with 93 mg/L revealed a degradation half-life of 19 days.
In the experiments using sediment extracts, the test substance 4-chlorobenzonitrile was totally degraded within 8 days. - Executive summary:
Anaerobic sediment samples with a solid content of 69 g/L and 93 mg/L were incubated at 25 °C under nitrogen atmosphere with 1.4 mg/L (= 0.01 mmol/L) and 0.14 mg/L, respectively.
In an other experiment sediment extracts were prepared by extracting sediment samples with 20 % glycerin. The protein fraction was precipitated using gel chromatography and ion-exchange chromatography. The benzonitrile metabolising portein fraction was used in the degradation experiments with 4-chlorobenzonitrile at a concentration of 1.4 mg/L = 0.01 mmol/L.
In sediment sample with 69 g solids/L 70 % of the initial test substance has been degraded after 40 days. The degradation experiment with 93 mg/L revealed a degradation half-life of 19 days.
In the experiments using sediment extracts, the test substance 4-chlorobenzonitrile was totally degraded within 8 days.
Transformation products were not detected in any of the experiments.
- Endpoint:
- biodegradation in water: sediment simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 308 (Aerobic and Anaerobic Transformation in Aquatic Sediment Systems)
- GLP compliance:
- no
- Radiolabelling:
- no
- Oxygen conditions:
- anaerobic
- Inoculum or test system:
- natural sediment
- Duration of test (contact time):
- <= 100 d
- Initial conc.:
- 1 µmol/L
- Based on:
- test mat.
- Compartment:
- sediment
- DT50:
- 18.8 d
- St. dev.:
- 2.2
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: r²=0.949
- Transformation products:
- yes
- No.:
- #1
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The degradation half-life of 4-chlorobenzonitrile in anaerobic sediment slurry is 18.8 (+/- 2.2) d.
- Executive summary:
The degradation of 4-chlorobenzonitrile was investigated in anaerobic sediment systems under laboratory conditions. 4-chlorobenzonitrile was incubated at an initial concentration of 1 µmol/L at 22 °C. The sediment/water ratio of the sediment used was 0.02, the organic carbon content and pH were 32.0 % and 7.3, respectively. Test substance degradation was followed by HPLC and UV measurements.
The degradation half-life of 4-chlorobenzonitrile under the conditions of the test was determined to be 18.8 (+/- 2.2) d.
Referenceopen allclose all
Description of key information
The degradation of 4-chlorobenzonitrile was investigated in anaerobic sediment
systems under laboratory conditions.
The degradation half-life of 4-chlorobenzonitrile under the conditions
of the test was determined to be 18.8 (+/- 2.2) d.
Key value for chemical safety assessment
- Half-life in freshwater sediment:
- 19 d
- at the temperature of:
- 22 °C
Additional information
The degradation of 4-chlorobenzonitrile was investigated in anaerobic sediment systems under laboratory conditions (see "623 -03 -0_4 -Chlorbenzonitril_kinetic_sediment_1992.pdf"). 4-chlorobenzonitrile was incubated at an initial concentration of 1 µmol/L at 22 °C. The sediment/water ratio of the sediment used was 0.02, the organic carbon content and pH were 32.0 % and 7.3, respectively. Test substance degradation was followed by HPLC and UV measurements.
The degradation half-life of 4-chlorobenzonitrile under the conditions of the test was determined to be 18.8 (+/- 2.2) d.
In additional experiments (see "623-03-0_4-Chlorbenzonitril BUA Stoffbericht") anaerobic sediment samples with a solid content of 69 g/L and 93 mg/L were incubated at 25 °C under nitrogen atmosphere with 1.4 mg/L (= 0.01 mmol/L) and 0.14 mg/L, respectively.
In addition an experiment was conducted using sediment extracts. The initial 4-chlorobenzonitrile concentration was 1.4 mg/L.
In sediment sample with 69 g solids/L 70 % of the initial test substance has been degraded after 40 days. The degradation experiment with 93 mg/L revealed a degradation half-life of 19 days.
In the experiments using sediment extracts, the test substance 4-chlorobenzonitrile was totally degraded within 8 days.
Transformation products were not detected in any of the experiments.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.