Registration Dossier
Registration Dossier
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EC number: 210-765-4 | CAS number: 623-03-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Peer reviewed data; publication of German Federal Environment Office in collaboration with GDCh (Society of German Chemists).
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: no guideline reported
- Principles of method if other than guideline:
- experimental results; no details on method, secondary reference
- GLP compliance:
- not specified
- Type of method:
- other: no data, secondary reference
- Partition coefficient type:
- other: no data, secondary reference
- Type:
- log Pow
- Partition coefficient:
- 2.47
- Remarks on result:
- other: experimental result, cited from SIS 2004; no further details reported
- Type:
- log Pow
- Partition coefficient:
- 2.24
- Remarks on result:
- other: experimental result, cited from Wu et al. 2001; no further details reported
- Conclusions:
- The log Kow of 4-chlorobenzonitrile is stated to be 2.24 and 2.47, respectively.
- Executive summary:
The log Kow for 4-chlorobenzonitrile as cited in the BUA Stoffbericht 265 is 2.47 and 2.24, respectively.
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.1
- Temp.:
- 20 °C
- Remarks on result:
- other: no pH specified
- Conclusions:
- The partition coeffient for p-chlorobenzontrile is 2.1 (Log Pow).
- Executive summary:
The study determined the partition coeffient according to EU Method A.8 (Partition Coefficient) using the HPLC method. The
log Pow for p-chlorobenzontrile was determined to be 2.1.
Referenceopen allclose all
Description of key information
The partition coefficient (n-octanol/water) log Kow is 2.47.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.47
- at the temperature of:
- 20 °C
Additional information
The log Kow as determined according to Guideline EU A.8 and GLP is 2.1. Other available data indicate slightly higher log Kow values of 2.24 and 2.47.
The higher the log Kow, the higher the risk of a substance to display unfavourable behaviour in the environment (e.g. bioaccumulation). The highest reported value for the log Kow of 2.47 is used as key value due to precautionary reasons.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
