Registration Dossier
Registration Dossier
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EC number: 237-158-7 | CAS number: 13674-84-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study was in accordance with OECD guideline and in compliance with GLP.
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Nothing to add in this field.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tris(2-chloro-1-methylethyl) phosphate
- EC Number:
- 237-158-7
- EC Name:
- Tris(2-chloro-1-methylethyl) phosphate
- Cas Number:
- 13674-84-5
- Molecular formula:
- C9H18Cl3O4P
- IUPAC Name:
- tris(2-chloro-1-methylethyl) phosphate
- Details on test material:
- TCPP
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- no data
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- yes
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- Exposure period of 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3
- Details on study design:
- no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- erythema score
- Time point:
- other: 1 hour
- Score:
- 2
- Max. score:
- 8
- Remarks on result:
- other: at the test site of two rabbits
- Irritation parameter:
- erythema score
- Time point:
- other: 24 hours
- Score:
- 1
- Max. score:
- 8
- Remarks on result:
- other: at the test site of two rabbits
- Irritation parameter:
- erythema score
- Basis:
- mean
- Score:
- 0.3
- Max. score:
- 8
- Reversibility:
- fully reversible within: 48 hours
- Remarks on result:
- other: two rabbits that show erythema effects
- Irritant / corrosive response data:
- no data
- Other effects:
- No other effect can be found in this study.
Any other information on results incl. tables
Nothing to add in this field.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- It can be concluted taht TCPP does not have a local irritant potential in the rabbit skin.
- Executive summary:
Nothing should add in this field.
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