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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: This study was in accordance with OECD guideline and in compliance with GLP.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2008

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
Principles of method if other than guideline:
Nothing to add in this field.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Tris(2-chloro-1-methylethyl) phosphate
EC Number:
237-158-7
EC Name:
Tris(2-chloro-1-methylethyl) phosphate
Cas Number:
13674-84-5
Molecular formula:
C9H18Cl3O4P
IUPAC Name:
tris(2-chloro-1-methylethyl) phosphate
Details on test material:
TCPP

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
yes
Amount / concentration applied:
no data
Duration of treatment / exposure:
Exposure period of 4 hours
Observation period:
14 days
Number of animals:
3
Details on study design:
no data

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Score:
0
Max. score:
8
Reversibility:
fully reversible within: 48 hours
Irritation parameter:
erythema score
Time point:
other: 1 hour
Score:
2
Max. score:
8
Remarks on result:
other: at the test site of two rabbits
Irritation parameter:
erythema score
Time point:
other: 24 hours
Score:
1
Max. score:
8
Remarks on result:
other: at the test site of two rabbits
Irritation parameter:
erythema score
Basis:
mean
Score:
0.3
Max. score:
8
Reversibility:
fully reversible within: 48 hours
Remarks on result:
other: two rabbits that show erythema effects
Irritant / corrosive response data:
no data
Other effects:
No other effect can be found in this study.

Any other information on results incl. tables

Nothing to add in this field.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
It can be concluted taht TCPP does not have a local irritant potential in the rabbit skin.
Executive summary:

Nothing should add in this field.