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Diss Factsheets
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EC number: 203-328-4 | CAS number: 105-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
For all aquatic endpoints, only data for freshwater species are available. There is no data available for marine species.
For acute toxicity to fish, three static studies with were conducted. The first study conducted according to OECD 203 reported a 96-hr LC50 of 1.2 mg/L based on nominal values, and 0.6 mg/L based on the geometric mean of the test substance concentrations. The two other studies were conducted according to the German DIN 38 412 with an incubation period of only 48 hours using the Golden orfe (Leuciscus idus) as test organism. In the first study an 48-hr LC50 value of 6 mg/L was reported, where the second one reported a 48 -hr LC0 of 12 mg/L. Both endpoints are related to nominal values too. The most reliable study is the one conducted according to OECD as it corresponds to currently valid standard. Furthermore, the lowest LC50 was observed here. It has therefore been selected as the key parameter.
For acute toxicity to invertebrates, also three studies are available, all conducted with the freshwater invertebrate Daphnia magna. One study was conducted according to OECD 202, reporting 48-hr EC50 of 21 mg/L based on nominal values. Two studies were conducted according to the DIN 38412 method and reported 24-hr EC values of 15 and 139 mg/L, respectively. Analytical verification of the test concentrations has only been conducted in the OECD study, confirming a sufficient stability of the test substance over the test period. Also, this study is the only one which was conducted to a currently valid standard, therefore resulting in the most reliable endpoint. For this reason, the EC50 of this study was selected as the key parameter although a lower EC50 was reported in one of the 24-hr studies.
For algae, a 72-hour study conducted according to OECD TG 201 using Scenedesmus subspicatus reported a NOEC of 4.2 mg/l and an EC50 of 6.2 mg/L, which is based on biomass.
For microorganisms, results from two aerobic and two anaerobic studies are available. The first, conducted with activated sludge according to OECD 209 reported an EC50 of 488.6 mg/L and an EC10 of 80.2 mg/l. The second one, conducted according to a modification of OECD 209 using Pseudomonas putida as the only test organism reported an EC10 of 1003 mg/L. In the anaerobic studies, both conducted according to the ETAD fermentation tube test, an 24 -hr EC0 of 63 mg/l and a 24 -hr toxicity threshold (TT) of 40 mg/L. The validity of both test could not be proven, as the respective guideline was not available. Furthermore, degradation processes in a STP are mainly aerobic. Therefore, both anaerobic studies were excluded from PNEC development. The endpoints derived from the unmodified OECD study were chosen as the key parameters, as the lowest values compared to the modified one were obtained here.
From the available data it can be deduced that fish are the most sensitive trophic level and the endpoint derived from this study should be used for deriving the PNEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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