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Diss Factsheets
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EC number: 203-328-4 | CAS number: 105-76-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
The BCF of 81.34 L/kg wet weight based on a measured log Pow of 3.4 was chosen as the most reliable endpoint.
Key value for chemical safety assessment
- BCF (aquatic species):
- 81.34 L/kg ww
Additional information
According to the requirements of the regulation, a study on bioaccumulation should be conducted if the log Pow of the substance is >= 3. As the measured log Pow of dibutyl maleate is 3.4, the criteria for conducting this study would be fulfilled. However, this value is only curtly above the trigger value of 3.
To decide whether a study on bioaccumulation would be necessary or not, two comparative (Q)SAR calculations were conducted first for the determination of the bioconcentration factor (BCF). For the first one, the measured log Pow of 3.4 was used as the calculation basis. For the second one, the estimated log Pow of 4.16 was taken. The BCF derived from the measured log Pow resulted in 81.34 L/kg wet weight, whereas the BCF based on the estimated value resulted in 258.1 L/kg wet weight, which is about three times higher than the one calculated with the measured value. It can be assumed that a measured BCF value would also be lower than an estimated one.
Furthermore, the modelling approach does not take into account any processes of biotransformation. The metabolism of dibutyl maleate in the liver catalyzed by esterases results in the formation of maleic acid and butanol, thus making it much more hydrophilic resulting in an increased excretion. Based on this, accumulation in the fish body is not expected. A study on bioaccumulation is therefore not necessary.
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