Registration Dossier
Registration Dossier
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EC number: 205-736-8 | CAS number: 149-30-4
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
Data source
Reference
- Reference Type:
- other: microfiche
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
- Principles of method if other than guideline:
- other: acute toxicity study
- GLP compliance:
- no
- Test type:
- other: acute toxicity study
Test material
- Reference substance name:
- Benzothiazole-2-thiol
- EC Number:
- 205-736-8
- EC Name:
- Benzothiazole-2-thiol
- Cas Number:
- 149-30-4
- Molecular formula:
- C7H5NS2
- IUPAC Name:
- 1,3-benzothiazole-2-thiol
- Details on test material:
- 2-mercaptobenzothiazole Dry Strain: batch 48/6/1001/0
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River rats
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Duration of exposure:
- 4 h
- Concentrations:
- 1270 mg/m3
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 1 270 mg/L air
Any other information on results incl. tables
Mortality: 0/5
Clinical symptoms: Ptosis and hypoactivity were observed after 90 minutes of exposure and lasted 55 minutes. No deaths were observed during exposure or the 14 day observation period which followed.
The average 2 -week body weight gain were within the normal limits.
Pathology: complete necropsies were done on all male and female rats used in this experiment when study was terminated at the end of the 14 -day post-exposure observation period. No gross tissue changes attributable to the effects of the test material were observed in any of the rats examined.
Particle size distribution:
A sample of airborn dust was collected from the test atmosphere for purpose of conducting a microscopic determination of particle size distribution. Particles were counted with respect to 4 size ranges, viz. 5 mircron or smaller, 6 to 10 micron, 11 to 25 microns and larger than 25 microns.
| Particle Size range(microns) | Number of particles counted | Percent of total counted |
| 1 -5 | 165 | 78.2 |
| 6 -10 | 22 | 10.4 |
| 11 -25 | 16 | 7.6 |
| < 25 | 8 | 3.8 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
