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EC number: 205-736-8 | CAS number: 149-30-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The acute dermal and oral toxicity of the test substance MBT is very low, indicated by oral LD50 values greater than 2000 mg/kg. The acute oral LD50 value in rats is = 2830 mg/kg bw (Monsanto Co. 1973, 1974) and the dermal LD50 value in rabbits is greater than 7940 mg/kg bw (Monsanto Co. 1973, 1974).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 800 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 7 940 mg/kg bw
Additional information
Acute toxicity: oral
The acute oral toxicity of MBT was evaluated in several acute oral toxicity studies in rats. Although the study results are reliable the test design of the studies does not comply with the current guidelines. In an acceptable documented study with Sprague-Dawley Albino rats a 20 % solution-suspension of MBT (THIOTAX powder) in corn oil was administered by gavage to 4 groups of 5 (mixed males and females) rats at doses of 3160, 3980, 5010 and 6310 mg/kg bw. A 14-day observation period followed administration. The acute oral LD50 for MBT for male and female rats was calculated to be 3800 mg/kg bw. Signs of intoxication noted were reduced appetite and activity (one to three days) in survivors and increased weakness, collapse and death in decedents. Autopsy of decedents showed lung hyperemia, slight liver discoloration, and gastrointestinal inflammation, whereas viscera of surviving animals appeared normal at sacrifice (Monsanto Co. 1975).
In another acceptable documented acute oral toxicity study with Sprague-Dawley rats, an oral LD50 of 2830 mg/kg bw was stated. The test substance MBT (THIOTAX MBT) was suspended in corn oil and were orally administered to four groups of 5 rats (mixed males and females) at doses of 2000, 2510, 3160 and 3980 mg/kg bw. The clinical signs observed were reduced appetite and activity (two to four days in survivors), and increased weakness, collapse, and death in decedents. Gross autopsy of decedents revealed hemorrhagic lungs, liver hyperemia, and acute gastrointestinal inflammation, whereas viscera of surviving animals appeared normal at sacrifice (Monsanto Co. 1974).
Moreover, the acute oral toxicity of different MBT batches received from different suppliers was tested in male Wistar rats. The LD50 values determined ranged from 7300 mg/kg bw to 9400 mg/kg bw (CIVO TNO 1977).
Acute toxicity: dermal
The acute dermal toxicity of MBT (THIOTAX powder) was evaluated in an acceptable documented acute dermal toxicity study with New Zealand Albino rabbits. Male and female rabbits (one to two animals per dose) were treated for 24 hours with a 40 % test substance suspension in corn oil at doses of 5010 and 7940 mg/kg bw. No mortality occurred. The dermal LD50 for MBT was greater than 7940 mg/kg bw. Clinical signs observed included reduced appetite and activity for 1 to 2 days. Viscera of animals appeared normal at sacrifice (Monsanto Co. 1975).
The findings from the above mentioned study were confirmed in an additional experiment with MBT (THIOTAX MBT) in New Zealand Albino rabbits, where a dermal LD50 greater than 7940 mg/kg was obtained (Monsanto Co. 1974).
Justification for classification or non-classification
No classification is required according to the classification criteria 67/548/EWG and regulation no. 1272/2008 (GHS).
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