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Diss Factsheets
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EC number: 225-533-8 | CAS number: 4904-61-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- DuPont Co. (1965). Unpublished Data, Haskell Laboratory Report No. 187-65; cited in DuPont Safety, Health & Environmental Excellence Center, Wilmington (Del., USA); Robust summary for 1,5,9-cyclododecatriene (revised).U.S. EPA, 46 pp (2003)
- Reference Type:
- publication
- Title:
- Robust summary for 1,5,9-cyclododecatriene (revised).
- Author:
- DuPont Safety, Health & Environmental Excellence Center, Wilmington (Del., USA)
- Year:
- 2 003
- Bibliographic source:
- U.S. EPA, 46 pp
Materials and methods
- Principles of method if other than guideline:
- Method: other: see reference
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 1,5,9-cyclododecatriene
- IUPAC Name:
- 1,5,9-cyclododecatriene
- Details on test material:
- purity: 99.8%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- -during exposure rat were housed individually in stainless wire mesh compartments
-following each exposure rats were housed individually
-Weight at study initiation: 230-270 g
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Remarks on MMAD:
- MMAD / GSD: no data
- Details on inhalation exposure:
- ADMINISTRATION / EXPOSURE
- Type of exposure: whole body, aerosol
- Post exposure period: none
- Doses: 1.64 mg/l
- Particle size: not reported
- Type or preparation of particles: spray nozzle with precision liquid metering pump
- resulting aerosol mist was directed into the main airstream entering the exposure chamber - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- no data
- Duration of treatment / exposure:
- 6 hours/day, 10 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1.64 mg/L
Basis:
nominal conc.
- No. of animals per sex per dose:
- 20
- Control animals:
- no
- Details on study design:
- Post-exposure period: none
- Positive control:
- not reported
Examinations
- Observations and examinations performed and frequency:
- CLINICAL OBSERVATIONS AND FREQUENCY:
- Clinical signs: at intervals throughout each exposure period
- Body weights were recorded
- Necropsies were performed - Sacrifice and pathology:
- Necropsies performed and tissue sections preserved for histopathological examinations: lung, liver, spleen, kidneys, bone marrow , brain
Results and discussion
Results of examinations
- Details on results:
- TOXIC RESPONSE/EFFECTS BY DOSE LEVEL:
- Mortality and time to death: no deaths
- Clinical signs: Peripheral vasodilation was noted throughout the study. A slight twitching only at the beginning of each exposure period through days 3 to 10 was observed. A lack of activity was observed throughout each exposure period.
- Body weight gain: Normal
- Gross pathology: The tissues of the major organs appeared normal at the terminal autopsy.
-substance did not produce any distinctive histological alterations in brain, lung , liver and bone marrow of the male albino rats
-only possible significant alteration is described as increased intracytoplasmatic granularity of renal proximal tubule epithelium but because of non- specific variable appearence of tubule alteration the difference was a rather inconsistent degree of granularity which was difficult to attribute to the test substance 1,5,9 cyclododecatriene
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
no further information
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.