Registration Dossier
Registration Dossier
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EC number: 202-696-3 | CAS number: 98-73-7
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data is contained in the EU risk assessment report of the substance - credibility is assumed. Reference to origin (RCC-CCR)
Data source
Referenceopen allclose all
- Reference Type:
- other: EU risk assessment report
- Title:
- No information
- Author:
- Federal Institute for Occupational Safety and Health, Division for Chemicals and Biocides Regulation, Germany
- Year:
- 2 009
- Bibliographic source:
- European Union Risk Assessment Report, 4-tert-butylbenzoic acid, CAS No: 98-73-7, EINECS No: 202-696-3, 4.1.2.7 Mutagenicity, p.66-67, Final Approved Version, July 2009
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 475 (Mammalian Bone Marrow Chromosome Aberration Test)
- GLP compliance:
- not specified
- Type of assay:
- chromosome aberration assay
Test material
- Reference substance name:
- 4-tert-butylbenzoic acid
- EC Number:
- 202-696-3
- EC Name:
- 4-tert-butylbenzoic acid
- Cas Number:
- 98-73-7
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 4-tert-butylbenzoic acid
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Any other information on results incl. tables
This in vivo chromosomal aberration test with rats was negative for single oral gavage doses of 600 (males) or 300 (females) mg/kg bodyweight.
Treatment led to toxic reactions in both genders and lethal effects in males (2/6). Pretests on toxicity demonstrated that in males lethal effects were observed for doses of 900 mg/kg (1/2) and 1000 mg/kg (1/2); in females lethal effects were observed for doses of 500 mg/kg (1/2), 600 mg/kg (1/2) and 800 mg/kg (2/2). A weak reduction of mitotic indices was observed at 24 h sampling in females (6.76 % in treated males, 5.02 % treated females vs. 7.24 % in control group).
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
The in vivo chromosomal aberration test with rats was negative.
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