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EC number: 239-387-8
CAS number: 15356-60-2
There is no reliable enough skin
sensitization study on D-Menthol according to current guideline methods.
However, based on the similarity within isomers, we can evaluate this
end-point based on read-across with the isomers.
Justification for Read-across:
Based on the comparable profiles on OECD-Toolbox of the different
menthols we can use them for read across studies. These isomers are
L-menthol (CAS 2216-51-5), D-menthol (CAS 15356-60-2) and DL-menthol
Moreover, a comparative physico-chemical profile of these isomers
reinforces this similarity.
As structural isomers, the members of the menthol category share the
same molecular weight. Of
particular importance to environmental effects and human effects
are the values for partition coefficient (log Kow around 3), vapour
pressure (from 17 Pa at 25°C for the DL-menthol to 21 Pa 25°C for the
natural L-menthol ) and water solubility ( moderately soluble from 410
mg/l at 25°C for the natural L-menthol to 470 mg/l at 25°C for the
DL-menthol). The read across is consistent based on these
No sensitization effects were observed in
guinea pig non maximization test (i.e Buehler test,
induction phase at 25% where there is no clue on mild irritation).
Moreover, there are several other
experimental and clinical published data sustaining
the lack of skin sensitisation potential of L-Menthol (constituting
On the whole, and considering the absence of alerts related to the
rotatoty powder of isomers the D-Menthol is concluding as none skin
sensitizer in accordance with the criteria of classification and
D-menthol is concluded not skin sensitizing and consequently does not
require any classification for this endpoint as set out in Regulation
(EC) No. 1272/2008.
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