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EC number: 239-387-8
CAS number: 15356-60-2
There is no data on D-menthol concerning the
aquatic toxicity endpoint. The evaluation is based on the L-menthol and
we used the read-across for this endpoint due to the comparable profiles.
Justification for Read-across:
Based on the comparable profiles on OECD-Toolbox of the different
menthols we can use them for read across studies. These isomers are
L-menthol (CAS 2216-51-5), D-menthol (CAS 15356-60-2) and DL-menthol
Moreover, a comparative physico-chemical profile of these isomers
reinforces this similarity.
As structural isomers, the members of the menthol category share the
same molecular weight. Of
particular importance to environmental effects and human effects
are the values for partition coefficient (log Kow around 3), vapour
pressure (from 17 Pa at 25°C for the DL-menthol to 21 Pa 25°C for the
natural L-menthol ) and water solubility ( moderately soluble from 410
mg/l at 25°C for the natural L-menthol to 470 mg/l at 25°C for the
DL-menthol). The read across is consistent based on these
Results from L-menthol:
The experimental short-term ecotoxicological data are available for the
following aquatic species on L-menthol:
Fish : LC50 at 96h = 15,6 mg/l
Daphnia : EC50 at 48h = 26,6 mg/l
Algae : EC 50 at 72h = 21,4 mg/l with a NOEC at 9,65 mg/l
The effective concentration 50% (EC50) for inhibition of activated
sludge respiration was determined as 237 mg/L. In view of this low
bacteriotoxic activity, it was concluded that release of the test
compound into the environment would most likely not adversely affect the
natural self purification capacity of surface water bodies.
There are no long term toxicity data on aquatic species or on
the PNEC is based on the available acute toxicity data with the related
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