Registration Dossier
Registration Dossier
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EC number: 607-485-3 | CAS number: 25015-63-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Raw data of acute toxicity study containing limited information but adequate for the purposes of hazard identification and classification.
- Justification for type of information:
- In contact with water 4,4,5,5-Tetramethyl-1,3,2-dioxaborolane undergoes a rapid hydrolysis to form boric acid (CAS 10043-35-3) and pinacol (CAS 76-09-5). Since boric acid seems to be the more toxic degradation product, the read across to this compound is scientifically justified.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- Boric acid
- EC Number:
- 233-139-2
- EC Name:
- Boric acid
- Cas Number:
- 10043-35-3
- Molecular formula:
- BH3O3
- IUPAC Name:
- boric acid
- Test material form:
- other: emulsion
- Details on test material:
- emulsifying agent was diluted with water in a ratio of 1:2
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 1000, 1990, 2510, 3160, 3980, 5010, and 10000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3 350 mg/kg bw
Any other information on results incl. tables
1000 mg/kg bw: 0% mortality
1990 mg/kg bw: 0% mortality
2510 mg/kg bw: 10% mortality
3160 mg/kg bw: 20% mortality
3980 mg/kg bw: 90% mortality
5010 mg/kg bw: 100% mortality
10000 mg/kg bw: 100% mortality
Applicant's summary and conclusion
- Conclusions:
- The LD50 of the test material was determined to be 3350 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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