Registration Dossier
Registration Dossier
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EC number: 202-448-4 | CAS number: 95-76-1
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- repeated dose toxicity: dermal
- Remarks:
- other: no data, migrated data set
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original report not yet available, migrated data set
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Substituted Anilines Task Force:unpublished draft,72 pages (12.07.1983)
- Author:
- Du Pont Company Data (no date)
- Bibliographic source:
- Cited in: Rautio: Synthetic Organic Chemical Manufactures Association
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data , migrated data set
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3,4-dichloroaniline
- EC Number:
- 202-448-4
- EC Name:
- 3,4-dichloroaniline
- Cas Number:
- 95-76-1
- Molecular formula:
- C6H5Cl2N
- IUPAC Name:
- 3,4-dichloroaniline
- Details on test material:
- IUCLID4 Test substance: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- Route of Administration: dermal
- Duration of treatment / exposure:
- 2 weeks, 6 h/d
- Frequency of treatment:
- 5 d/week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
60 mg/kg bw
Basis:
- Remarks:
- Doses / Concentrations:
135 mg/kg bw
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- other: no data
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
low dose: Skin irritation, no other pathophysiological changes, increase in methemoglobin formation, reduction of erythrocytes and hemoglobin.
high dose: after 6 to 8 days 50 % of the animals were dead, increase in methemoglobin and glutamat pyruvat transaminase,reduction of erythrocytes and hemoglobin.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
