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EC number: 233-116-7 | CAS number: 10038-98-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- see section 13 of IUCLID for read accross justification
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):GeO2
- Molecular formula (if other than submission substance):GeO2
- Physical state:powder
- Composition of test material, percentage of components:>96%active
- Lot/batch No.:29506:856
- Stability under test conditions:stable under normal conditions
- Other:colour:white
-solubility: water: hexagonal structure:0.447%, tetrogonal structure non-soluble - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations:0-6.24-12.5-25-50-100 mg GeO2/L
- Sampling method:samples were taken at the beginning and at the end of the test. 1 replica sample was taken of each test concentration. The samples were placed in PE bottles and 1% HNO3 was added to each sample.
- Sample storage conditions before analysis:stored at room temperature until shipment - Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name:Daphnia magna
- Source:LISEC laboratory culture
- Age at study initiation (mean and range, SD):less than 24h - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- according to OECD 202
- Test temperature:
- 21.5-22.0 °C
- pH:
- 7.89-8.34
- Dissolved oxygen:
- 7.54-7.91
- Nominal and measured concentrations:
- Nominal concentrations: 0-6.24-12.5-24.9-99.8 mg GeO2/L
measured concentrations: 0-6.34-12.95-25.55-51.3-102.5 mg GeO2/L - Details on test conditions:
- TEST SYSTEM
- Test vessel:50 mg borosilicate glass beakers
- Type (delete if not applicable): open
- Material, size, headspace, fill volume:borosilicate glass beakers, 50 ml
- No. of organisms per vessel:5
- No. of vessels per concentration (replicates):4
- No. of vessels per control (replicates):4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water:ISO 6341
OTHER TEST CONDITIONS
- Photoperiod:14h daily photoperiod
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
TEST CONCENTRATIONS
- Spacing factor for test concentrations:
- Justification for using less concentrations than requested by guideline:
- Range finding study: yes
- Test concentrations:0-181 mg GeO2/L
- Results used to determine the conditions for the definitive study:upt to 18.1 mg GeO2/L: 0% immobilisation: 181 mg GeO2/L: 100% immobilisation - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 67.5 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- act. ingr.
- Basis for effect:
- mortality
- Remarks on result:
- other: mean of 3 EC50s determined with Probit analysis (95%CI:53.1-93.1)
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 12.95 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality of control: 0
- Reported statistics and error estimates:
- The EC50 values and their associated 95% confidence intervals (95%CI:53.1-93.1)were calculated using the TOXDAT Multi-method program (Stephan, 1985)
- Validity criteria fulfilled:
- yes
- Conclusions:
- Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute aquatic ecotoxicity
- Executive summary:
Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute aquatic ecotoxicity. The 48 hrs LC50 was 67.5 mg GeO2/L, or 46.9 mg Ge/L.
Reference
Description of key information
Results on 2 species were available on the short-term toxicity to aquatic invertebrates. The LISEC study was conducted with GeO2 according to standard protocol. No studies on marine species were available.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 138 mg/L
Additional information
The 48h LC50 in the LISEC 2001 study was 67.5 mg GeO2/L. This corresponds to 138 mg GeCl4/L.
The study on Hyalella gave a non-bound EC50 in tap water (> 3.1 mg/l). A low EC50 was observed in very soft water; this corresponds to a EC50 for GeCl4 of 0.62 mg /L
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