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EC number: 233-116-7 | CAS number: 10038-98-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- see section 13 of IUCLID for read accross justification
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations:0-6-12-24-48-96
- Sampling method:samples were taken at the start and the end of the test. 1 replica sample was taken of each test concentration. The samples were placed in PE bottles and 1% HNO3 was added to each sample.
- Sample storage conditions before analysis:room temperature before shipping - Vehicle:
- no
- Details on test solutions:
- OECD guideline 203
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name:Danio rerio
- Source:De Siervis
- Length at study initiation (length definition, mean, range and SD):3.48 +- 0.04 cm
- Weight at study initiation (mean and range, SD):0.429 +- 0.042
- Feeding during test:no - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- according to OECD 203
- Test temperature:
- 22.2-26.6°C
- pH:
- 8.04-8.56
- Dissolved oxygen:
- 7.49 mg O2/L
- Nominal and measured concentrations:
- nominal concentrations: 0-6-12-24-48-96 mg geO2/L
measured concentrations: 0-6.47-12.95-25.05-50.35-103.5 mg geO2/L - Details on test conditions:
- TEST SYSTEM
- Test vessel:3L borosilicate glass beakers
- Type (delete if not applicable): open
- Material, size, headspace, fill volume:3L borosilicate glass beakers
- No. of organisms per vessel:7
- Biomass loading rate:7 fish per 3L corresponds with 1g fish /L
OTHER TEST CONDITIONS
- Photoperiod:14h daily photoperiod
- Light intensity:Philips TL-33 lamps yielding at the surface of the test solutions
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
TEST CONCENTRATIONS
- Spacing factor for test concentrations:2
- Range finding study:yes
- Test concentrations:0-0.2-0.58-1.81-5.76-18.1 mg Ge02/L
- Results used to determine the conditions for the definitive study:no mortality was observed in the range finding study - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 96 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 96 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: unbound NOEC
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 103.5 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- ca. 103.5 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: unbound NOEC
- Validity criteria fulfilled:
- yes
- Conclusions:
- Tests done according to standard protocol. Good quality and considered useful for setting the reference value for acute aquatic ecotoxicity.
- Executive summary:
Tests done according to standard protocol.
The 96 h LC50 was >103.5 mg GeO2/L, or >71.8 mg Ge/L.
Reference
Description of key information
Only one study result was available on the short-term toxicity to fish. This study was conducted with GeO2 according to standard protocol.
The 96hrs LC50 was 103.5mg GeO2/L.
No studies on marine species were available.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 211 mg/L
Additional information
The study was conducted with GeO2 as test substance. GeCl4 hydrolysis in contact with water to GeO2 and HCl.
GeCl4 + 2H2O ==> GeO2+ 4 HCl
The ecotoxicity endpoint from GeO2 can be expressed as GeCl4 using following formula: LC50 (expressed as mg GeCl4/L) = (Molecular weight GeCl4/ Molecular weight GeO2)* LC50 (expressed as mg GeO2/L).
The 96h LC50 was 103.5 mg GeO2/L. This corresponds to 211 mg GeCl4/L
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