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Diss Factsheets
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EC number: 221-657-1 | CAS number: 3179-47-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: OSHA toxicity screening test. Limited documentation of the study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Guideline:
- other: OSHA Toxicity Screening Test
- GLP compliance:
- no
- Test type:
- other: saturated atmosphere
- Limit test:
- yes
Test material
- Reference substance name:
- Isodecyl methacrylate
- EC Number:
- 249-978-2
- EC Name:
- Isodecyl methacrylate
- Cas Number:
- 29964-84-9
- Molecular formula:
- C14H26O2
- IUPAC Name:
- 8-methylnonyl methacrylate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- Average body weight: 190 grams
Administration / exposure
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: inhalation chamber
- Exposure chamber volume: 325 liter
- Source and rate of air: Air flow- thru generator, 9.9 L/min at 29.92 mm Hg
- Temperature: 25 °C
Time allotted for equilibrium: 161 min - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 1 h
- Concentrations:
- Average nominal concentration = 0.9 mg/L air
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- > 0.9 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 1 h
- Mortality:
- No deaths.
- Clinical signs:
- other: No untoward behavioral reactions.
- Body weight:
- The average body weight gain was 52 grams.
- Gross pathology:
- Necropsy examinations revealed no gross pathologicc alterations.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- In an acute inhalation toxicity study on Isodecyl methacrylate with Albino Rats, no signs of toxicity were observed within a 14 day observation period after one-hour exposure to a saturated atmosphere (0.9 mg/L) at 35 °C.
- Executive summary:
In an OSHA toxicity screening test in Albino rats on acute inhalation toxicity with Isodecyl methacrylate, no mortalities, behavioral abnormalities or gross pathologic alterations were observed after one hour exposure within a 14 day observation period.
The determined LC0 was > 0.9 mg/L at 35 °C (saturated atmosphere).
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