Registration Dossier
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EC number: 605-150-6 | CAS number: 15848-49-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Key data:
EbC50 (72h) = 12.7 mg/L (biomass) [based on arith. mean measured]
ErC50 (72h) = 29.2 mg/L (specific growth rate) [based on geom. mean measured]
EyC50 (72h) = 13.3 mg/L (yield) [based on arith. mean measured]
EbC10 (72h) = 5.77 mg/L (biomass) [based on arith. mean measured]
ErC10 (72h) = 10.6 mg/L (specific growth rate) [based on geom. mean measured]
EyC10 (72h) = 6.92 mg/L (yield) [based on arith. mean measured]
NOEC (72h) = 4.38 mg/L (biomass and yield) [based on arith. mean measured]
NOEC (72h) = 8.21 mg/L (specific growth rate) [based on geom. mean measured]
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 29.2 mg/L
- EC10 or NOEC for marine water algae:
- 10.6 mg/L
Additional information
The toxicity test to aquatic algae (Scheerbaum 2012) performed according to EPA OPPTS 850.5400, EPA OPPTS 850.1000 and GLP was rated with RL=1 (reliable without restrictions) and used as a key study.
In this study the test item was found to inhibit the growth of the freshwater green alga Pseudokirchneriella subcapitata after 72 with the following effect values (mean measured concentrations):
The EC50-values with 95 % confidence intervals for inhibition of biomass (EbC50), specific growth rate (ErC50) and yield (EyC50) after 72 hours were 12.7 (11.6 – 13.7) mg/L, 29.2 (28.0 – 30.6) mg/L and 13.3 (12.3 – 14.2) mg/L, respectively.
The EC10-values with 95 % confidence intervals for inhibition of biomass (EbC10), specific growth rate (ErC10) and yield (EyC10) after 72 hours were 5.77 ( 3.74 – 7.23) mg/L, 10.6 (9.37 – 12.0) mg/L and 6.92 (5.65 – 8.38) mg/L, respectively.
The NOEC-values for inhibition of biomass, specific growth rate and yield after 72 hours were 4.38 mg/L, 8.21 mg/L and 4.38 mg/L, respectively.
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