Registration Dossier
Registration Dossier
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EC number: 205-855-5 | CAS number: 156-43-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Publication in original language, not translated.
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative toxicological assessment of p-phenetidine and cyanoethyl-p-phenetidine
- Author:
- Vasilenko NM, Volodchenko VA, Nakonechny AA, Sadokha ER
- Year:
- 1 972
- Bibliographic source:
- Farmakologiya i Toksikologiya (Moscow). Volume 35, Issue 3, p. 367-9.
Materials and methods
- Principles of method if other than guideline:
- Rats were administered a single intragastric dose of p-phenetidine.
- GLP compliance:
- no
Test material
- Reference substance name:
- p-phenetidine
- EC Number:
- 205-855-5
- EC Name:
- p-phenetidine
- Cas Number:
- 156-43-4
- Molecular formula:
- C8H11NO
- IUPAC Name:
- 4-ethoxyaniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- A single dose of p-phenetidine
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 580 mg/kg bw
Any other information on results incl. tables
The substance did not show cumulative properties.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 = 580 mg/kg bw
- Executive summary:
In a test on albino rats with a single intragastric introduction of para-phenetidine the LD50 for the substance was found to be 580 mg/kg bw. The substances showed no cumulative properties. Poisoning with this substance is characterized by the development of methemoglobinemia.
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