Registration Dossier
Registration Dossier
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EC number: 205-855-5 | CAS number: 156-43-4
Endpoint summary
Administrative data
Description of key information
Weight of evidence:
Oral acute toxicity: data obtained from single administration in rats. LD50 = 580 mg/kg bw in rats.
Oral acute toxicity: data obtained in rats. LD50 = 540 ± 34 mg/kg bw in rats and 600 ± 21 mg/kg bw in mice.
Key value for chemical safety assessment
Additional information
Weight of evidence:
Acute toxicity: oral:
In a test on albino rats with a single intragastric introduction of para-phenetidine the LD50 for the substance was found to be 580 mg/kg bw. The substance showed no cumulative properties. Poisoning with this substance is characterized by the development of methemoglobinemia.
The toxic properties of p-phenetidine were studied after oral administration. The LD50 for white rats and mice correspond to 540 ± 34 and 600 ± 21 mg/kg bw respectively.The results are processed by probit analysis of Prozorovsky.
Justification for classification or non-classification
The substance is included in Table 3 of Annex VI of CLP Regulation (harmonised classification and labelling) and classified as:
Acute Oral Toxicity Category 4* (minimum classification)
Acute Dermal Toxicity Category 4* (minimum classification)
Acute Inhalation Toxicity Category 4* (minimum classification)
The available information on acute oral toxicity supports the classification as Acute Oral Toxicity Category 4.
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