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EC number: 268-028-8 | CAS number: 67990-05-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Nanomaterial dustiness
Administrative data
- Endpoint:
- nanomaterial dustiness
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EN 15051-2 (Workplace exposure. Measurement of the dustiness of bulk materials - Rotating drum method)
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 55992-1:2006
- Version / remarks:
- Determination of a parameter for the dust formation of pigments and extenders - Part 1: Rotation method
- GLP compliance:
- not specified
- Type of method:
- rotating cylinder
Test material
- Reference substance name:
- N-(5-chloro-2-methoxyphenyl)-3-hydroxy-4-[[2-methoxy-5-[(phenylamino)carbonyl]phenyl]azo]naphthalene-2-carboxamide
- EC Number:
- 268-028-8
- EC Name:
- N-(5-chloro-2-methoxyphenyl)-3-hydroxy-4-[[2-methoxy-5-[(phenylamino)carbonyl]phenyl]azo]naphthalene-2-carboxamide
- Cas Number:
- 67990-05-0
- Molecular formula:
- C32H25ClN4O5
- IUPAC Name:
- N-(5-chloro-2-methoxyphenyl)-3-hydroxy-4-[[2-methoxy-5-(phenylcarbamoyl)phenyl]diazenyl]-2-naphthamide
- Test material form:
- solid: nanoform
Constituent 1
Data gathering
- Instruments:
- Heubach dust meter
The substance to be investigated is kept in motion in a dust generation device consisting of a rotating drum (volume: 2.2 L, 30 rpm) with integrated baffle plates. After a short period of upwards transportation the substance subsequently falls down within the drum. The airborne part of the dust is taken out of the drum by an axial air current of 20 L/min. In the process, both the airborne dust already contained in the substance and the airborne dust which has been newly generated through abrasion within the drum are collected.
Modified Heubach procedure
With the Heubach dust meter described above alone, it is not possible to separate inhalable, thoracic and alveolar dust fractions as defined in DIN EN 481. Therefore, the Heubach dust meter was modified by DMT in a way that a seven-stage cascade impactor was inserted instead of the filter. This interconnection of the rotating drum and the cascade impactor requires the following special approach: Whereas the rotating drum requires an air flow rate of approx. 20 L/min in accordance with the manufacturer’s specifications, the cascade impactor requires an air flow rate of 40 L/min in order to work properly. Therefore, 20 L/min of additional air is fed into the system via the coarse dust separator. By introducing a glass tubing, the dust generated in the rotating drum is now directly conveyed into the cascade impactor. The vessel used as the coarse dust separator in the original set-up now only serves as a tool to introduce additional air and for the purpose of visual inspection. The 20 L/min additional air required for the functioning of the cascade impactor are channelled off the exhaust air current of the cascade impactor via a three-way valve on the pressure side of the vacuum pump. Due to the present layout, the sampling tube of the cascade impactor is relatively long. However, due to the high air flow in the tube, which is approx. 10 m/s, any loss of sedimentation during the transportation of dust in the tube is excluded.
Determination of dust fractions with the cascade impactor
The cascade impactor is suitable for particle size determinations of airborne dust. Due to its small dimensions, it can be used e.g. for sampling in ducts or workplaces as well as in the laboratory for particle size determination of substance samples. The device works in accordance with the following principle: if a dust-containing air current encounters an obstacle and is thus redirected, the more inertial particles of the dust cannot follow this change in direction. The individual cascade stages of the impactor are designed in a way that the dust-containing air enters the first stage from above, is redirected and accelerated by a nozzle ring against the separator ring. While some of the dust particles deposit, the air current is redirected and reaches the second stage. From stage to stage the diameter of the nozzles is decreasing. Thus, the dust is progressively separated through redirections of the air current from the exterior to the interior and increasing air velocity and therefore, depositing particles on each stage according to the particle size. For a better adhesion of the deposited particles the rings are coated with a thin oil film. In the seven-stage cascade impactor used here the dust was separated into 7 fractions between approx. 0.3 μm and 30 μm. A scale with a resolution of 0.01 mg (Shimadzu AUW-220D, D-K-17702-01-00) was used to determine the mass of deposited quantities of dust on the individual impactor stages.
Results and discussion
Dustiness indexopen allclose all
- Mean:
- ca. 3.79 other: %
- Remarks on result:
- other: Relative amounts of used quantity
- Remarks:
- Dustiness, alveolar fraction
- Mean:
- ca. 12.81 other: %
- Remarks on result:
- other: Relative amounts of used quantity
- Remarks:
- Dustiness, thoracic fraction
- Mean:
- ca. 31.66 other: %
- Remarks on result:
- other: Relative amounts of used quantity
- Remarks:
- Dustiness, inhalable fraction
Any other information on results incl. tables
For PIGMENT RED-269, the respirable fraction represented 3.79 % of the quantity of the substance used under the modified Heubach procedure.
As the small rotation drum method according to EN 17199-4 might be more appropriate to assess the dustiness for this type of nanomaterial, a study based on this method is planned. However, due to the capacity of the laboratory it has been delayed and it will be conducted as soon as possible.
Applicant's summary and conclusion
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