Registration Dossier
Registration Dossier
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EC number: 905-013-3 | CAS number: -
Carcinogenicity
Administrative data
Description of key information
The substance is not carcinogenic in rats and mice.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Additional information
- Carcinogenicity, oral:
There is no data on Reaction mass of isomenthone and trans-menthone
According to reliable chronic (103-week) repeated dose toxicity studies in rat and mouse, the NOAEL for the read-across compound LD-menthol was not identified, since at the highest intake dose no adverse effect was observed, i.e at 375 mg/kg bw/day (370 mg/kg bw/day for Isomenthone and Trans-menthone) in rat and at 667 mg/kg bw/day (658 mg/kg bw/day for isomenthone and Transmenthone) in mouse.
Justification for selection of carcinogenicity via oral route endpoint:
A reliable chronic oral toxicity study with the substance is available, which revealed that the substance is not carcinogenic to rats.
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