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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 905-013-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: published study with few data on dermal absorption
Data source
Reference
- Reference Type:
- publication
- Title:
- In vitro evaluation of the permeation through reconstructed human epidermis of essentials oils from cosmetic formulations
- Author:
- Gabbanini S, Lucchi E, Carli M, Berlini E, Minghetti A, Valgimigli L
- Year:
- 2 009
- Bibliographic source:
- PMID:19535210 J Pharm Biomed Anal 50(3):370-6
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Experimental study validation design
- GLP compliance:
- no
Test material
- Reference substance name:
- l-Menthone
- IUPAC Name:
- l-Menthone
- Details on test material:
- - Name of test material (as cited in study report): (-)-menthone
Constituent 1
- Radiolabelling:
- no
Administration / exposure
- Details on study design:
- Essential oil mixture employed for the analytical validation was used (5%. w/w) to prepare the massage oil, which represented the donor medium in our investigation. A diffusion cell designed for this work, whose geometry was optimized to accommodate SkinEthic(R) RHE 4.0 cm2 disks. The receptor medium composition was chosen to mimic physiological extracellular fluids; polysorbate-20 (3%, w/w) and isopropanol (0.25%, w/w) were added to increase the solubility of apolar analytes, in line with other in vitro studies and with OECD recommendations. The concentration of such solubilizers was however kept as low as possible to avoid toxicity in RHE. At the temperature of 34 ± 1 °C the donor compartment was loaded with 1.0 mL oil of oleolite so to operate under "infinite dose" conditions and avoid significant decrease of analytes' concentration in the donor during the diffusion experiment. The percutaneous absorption profile was determined by HS/SPME-GC-MS analysis of the receptor medium, sampling from each diffusion cell at regular intervals. Under the steady-state approximation, which is valid when the concentration gradient through the skin membrane is constant, the diffusion process occurs in accordance with Fick's first law.
Results and discussion
Any other information on results incl. tables
Percutaneous penetration permeability coeficient (Ps) of Menthone from applied essential oil mixture through SkinEthic(R) reconstructed human epidermis (RHE) was 0.40±0.01 x10^-3 cm/h.
Applicant's summary and conclusion
- Conclusions:
- Investigated menthone in essential oil mixture was found to cross SkinEthic(R) RHE with a permeability coeficient Ps=0.4±0.01 x 10^-3 cm/h.
- Executive summary:
The diffusion kinetic for Menthone chosen as analytical marker of a mixture of plant essential oils contained in cosmetic formulation was probed by HS/SPME-GC-MS analysis and elaborated according to Fick's first law to obtain the skin permeability coeficient (Ps=0.40 x10^-3 cm/h).
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