Registration Dossier
Registration Dossier
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EC number: 245-247-7 | CAS number: 22818-40-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Results with HPGM:
Amesnegative with or without metabolic activation.
Mammalian cell gene mutation assay (TK locus, OECD 476, GLP): negative with or without metabolic activation.
Results with PG:
Amesnegative with or without metabolic activation
Short description of key information:
By analogy with D(-)-alpha-Phenylglycine (PG, CAS 875-74-1) and D(-)-p-Hydroxyphenylglycine methyl ester (HPGM, CAS 37763-23-8), D(-)-p-Hydroxyphenylglycine (HPG) is not considered as a genotoxic substance.
(Read-across proposed have been checked using the OECD Toolbox v. 1.1.01)
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Data are conclusive but not sufficient for classification according to CLP criteria (Regulation (EC) No 1272/2008). No classification is proposed regarding genetic toxicity according to CLP criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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