Registration Dossier
Registration Dossier
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EC number: 245-247-7 | CAS number: 22818-40-2
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Results with HPGM:
Maximisation (OECD 406, GLP) (Pels Rijcken WR, Notox, 2000): negative (vehicle = 1% aqueous carboxymethyl cellulose) (key study)
Buehler test (OECD 406, GLP) (Pels Rijcken WR, Notox, 2000): negative (vehicle = 1% aqueous carboxymethyl cellulose) (supporting study)
Maximisation (OECD 406, GLP) (Pels Rijcken WR, Notox,1996): positive (vehicle =corn oil) (not reliable)
In the end nineties Deretil has noticed that in particular esters resulted in positive M&K tests, whereas the practice did not show any effect.
Deeper analysis by an expert and of existing studies revealed that the use of corn oil could be the cause of that.
Therefore we decided to redo the test for HPGM with 1% aqueous carboxymethylcellulose.
(corn-) oil gives sooner positive GPMT responses compared to Propylene Glycol.
Results with PG:
D(-)alpha-Phenylglycine (PG) is not a skin sensitiser in an LLNA test.
Migrated from Short description of key information:
By analogy with D(-)-alpha-Phenylglycine (PG, CAS 875-74-1) and D(-)-p-Hydroxyphenylglycine methyl ester (HPGM, CAS 37763-23-8), D(-)-p-Hydroxyphenylglycine (HPG) is not considered as a skin sensitiser.
(Read-across proposed have been checked using the OECD Toolbox v. 1.1.01)
Justification for classification or non-classification
Data are conclusive for skin sensitisation, but not sufficient for classification according to CLP criteria (Regulation (EC) No 1272/2008). No data is available by inhalation.
No classification is proposed for sensitisation according to CLP criteria.
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