Registration Dossier
Registration Dossier
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EC number: 273-732-3 | CAS number: 69012-32-4 By-product of smelting of phosphate rock, silica and coke in manufacture of phosphorus.
Endpoint summary
Administrative data
Description of key information
Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test (OECD 422)
- NOAEL: 1000 mg/kg bw/day
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
The key study was a 28-day Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test performed according to OECD 422 under GLP conditions, in which a NOAEL of 1000 mg/kg bw/day was established based on the absence of adverse effects up to the highest dose.
Justification for classification or non-classification
When considering the NOAEL of 1000 mg/kg bw/day and the guidance values for classification as outlined in Annex I of 1272/2008/EC (significant effect observed at 300 mg/kg bw/day) and Annex VI of 67/548/EEC (significant effect observed at 150 mg/kg bw/day), P-slag does not need to be classified for repeated dose toxicity.
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