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EC number: 907-349-6
CAS number: -
- Induction: Erythema was generally absent to well defined during the
induction phase. One animal exhibited moderate to severe erythema during
the first induction.
- Challenge: Due to the moderate to severe response of one animal during
the first induction, interpretation of the challenge reactions were
based on the individual induction responses. Seven of ten animals
exhibited positive responses to the first 6 hour challenge exposure to a
0.1% concentration of the test article. Eight of ten animals exhibited
positive responses following the second challenge.
- Systemics: All animals survived in generally good health. Instances of
emaciation and soiling of the anogenital area were noted during the
- Conclusion: Octadecyl isocyanate is a sensitizer.
- Induction: Erythema was absent to slight during the first two
inductions, and absent to well defined during inductions 3 and
4.Thereafter, erythema was generally mild to severe.
- Challenge: All animals exhibited positive responses following both 6
hour challenge exposures to a non-irritating 0.1% concentration of DNCB.
- Systemics: All animals survived in generally good health with one
animal exhibiting instances of emaciation and soiling of the anogenital
- Conclusion: DNCB (dinitrochlorobenzene) is a sensitizer.
A Buehler test in guinea pigs revealed a skin sensitising
potential of octadecyl isocyanate (0.1% induction and challenge conc.,
>= 70 % incidence of sensitisation) according to a method similar to
OECD Guideline 406.
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