Registration Dossier
Registration Dossier
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EC number: 907-349-6 | CAS number: -
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
A Buehler test in guinea pigs revealed a skin sensitising potential of octadecyl isocyanate (0.1% induction and challenge conc., >= 70 % incidence of sensitisation) according to a method similar to OECD TG 406 (Fritz 1989).
Respiratory sensitisation
Endpoint conclusion
- Additional information:
No data available.
Justification for classification or non-classification
Skin sensitisation
Not classified under Annex I of Directive 67/548/EEC or Annex VI-1 of Regulation (EC) No 1272/2008. Deviating from that a skin sensitising potential in guinea pigs detected in a Buehler test leads to the following classification according to Annex I of Regulation (EC) No 1272/2008: Category 1 (H317: May cause an allergic skin reaction).
Respiratory sensitisation
Not classified under Annex I of Directive 67/548/EEC or Annex VI-1 of Regulation (EC) No 1272/2008. Deviating from that a self classification according to Annex I of Regulation (EC) No 1272/2008 with Category 1 (H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled) is recommended since isocyanates are known as respiratory sensitisers.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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