Registration Dossier
Registration Dossier
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EC number: 202-523-1 | CAS number: 96-67-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- DPIM : HMY500
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials):-28ZPAK Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia.: , 1972, 181.
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : OY2357500
- Author:
- RTECS handbook
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances):-85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1052,1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Standard Draize test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-amino-2-hydroxy-5-nitrobenzenesulphonic acid
- EC Number:
- 202-523-1
- EC Name:
- 3-amino-2-hydroxy-5-nitrobenzenesulphonic acid
- Cas Number:
- 96-67-3
- Molecular formula:
- C6H6N2O6S
- IUPAC Name:
- 3-amino-2-hydroxy-5-nitrobenzenesulphonic acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- 24H
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24H
- Max. score:
- 100
- Remarks on result:
- other: Dose:100 mg/24H ; Moderate irritation
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The substance is moderately irritating to rabbit eye.
- Executive summary:
The 24 h study of the target chemical, 3-amino-2-hydroxy-5-nitrobenzenesulphonic acid, on rabbits indicate that the substance is moderately irritant to eyes and so will be considered for classification in Eye irritation category 2.
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