Registration Dossier
Registration Dossier
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EC number: 202-523-1 | CAS number: 96-67-3
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This substance is a structural analog (read across) to the target chemical, 3-amino-2-hydroxy-5-nitrobenzenesulphonic acid and have more than 92.6 % similarity.
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 96-93-5
- Author:
- Danish EPA Model
- Year:
- 2 012
- Bibliographic source:
- QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database; Commercial
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Sensitization (dermal).Multicase model A33.
- GLP compliance:
- no
- Type of study:
- other: GPMT or human experience
Test material
- Reference substance name:
- 3-amino-4-hydroxy-5-nitrobenzenesulphonic acid
- EC Number:
- 202-546-7
- EC Name:
- 3-amino-4-hydroxy-5-nitrobenzenesulphonic acid
- Cas Number:
- 96-93-5
- IUPAC Name:
- 3-amino-4-hydroxy-5-nitrobenzenesulfonic acid
- Details on test material:
- - Name of test material: 3-amino-4-hydroxy-5-nitrobenzenesulphonic acid
- Molecular formula: C6H6N2O6S
- Molecular weight: 234.19
- Substance type: organic
Constituent 1
In vivo test system
Test animals
- Species:
- other: Guinea pig or human
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: not specified
- Vehicle:
- unchanged (no vehicle)
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- Sensitising
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Clinical observations: Sensitising.
Any other information on results incl. tables
Positive sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- 3-amino-4-hydroxy-5-nitrobenzenesulphonic acid is estimated to be skin sensitising.
- Executive summary:
3-amino-4-hydroxy-5-nitrobenzenesulphonic acid is estimated to be skin sensitising. Since this substance is a structural analog (read across) to the target chemical, 3-amino-2-hydroxy-5-nitrobenzenesulphonic acid, having more than 92.6 % similarity and thus the toxicity effect can be considered for the target substance as well. Thus it can be infered that 3-amino-2-hydroxy-5-nitro benzene sulphonic acid is skin sensitising.
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